USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at the DNA replication fork

The AAA(+) ATPase VCP regulates the extraction of SUMO and ubiquitin-modified DNA replication factors from chromatin. We have previously described that active DNA synthesis is associated with a SUMO-high/ubiquitin-low environment governed by the deubiquitylase USP7. Here, we unveil a functional coop...

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Detalles Bibliográficos
Autores principales: Franz, André, Valledor, Pablo, Ubieto-Capella, Patricia, Pilger, Domenic, Galarreta, Antonio, Lafarga, Vanesa, Fernández-Llorente, Alejandro, de la Vega-Barranco, Guillermo, den Brave, Fabian, Hoppe, Thorsten, Fernandez-Capetillo, Oscar, Lecona, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527565/
https://www.ncbi.nlm.nih.gov/pubmed/34644576
http://dx.doi.org/10.1016/j.celrep.2021.109819

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