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Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy

BACKGROUND: The sensitivity of regular arrangement of collecting venules (RAC)-positive pattern for predicting Helicobacter pylori (H. pylori)-negative status greatly altered from 93.8 to 48.0% in recent two decades of various studies, while the reason behind it remained obscure. The aim of this stu...

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Autores principales: Yuan, Cong, Lin, Xue-Mei, Ou, Yan, Cai, Lin, Cheng, Qian, Zhou, Ping, Liao, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527606/
https://www.ncbi.nlm.nih.gov/pubmed/34670510
http://dx.doi.org/10.1186/s12876-021-01960-w
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author Yuan, Cong
Lin, Xue-Mei
Ou, Yan
Cai, Lin
Cheng, Qian
Zhou, Ping
Liao, Juan
author_facet Yuan, Cong
Lin, Xue-Mei
Ou, Yan
Cai, Lin
Cheng, Qian
Zhou, Ping
Liao, Juan
author_sort Yuan, Cong
collection PubMed
description BACKGROUND: The sensitivity of regular arrangement of collecting venules (RAC)-positive pattern for predicting Helicobacter pylori (H. pylori)-negative status greatly altered from 93.8 to 48.0% in recent two decades of various studies, while the reason behind it remained obscure. The aim of this study was to investigate the value of RAC as an endoscopic feature for judging H. pylori status in routine endoscopy and reviewed the underlying mechanism. METHODS: A prospective study with high-definition non-magnifying endoscopy was performed. RAC-positive and RAC-negative patients were classified according to the collecting venules morphology of the lesser curvature in gastric corpus. Gastric biopsy specimens were obtained from the lesser and greater curvature of corpus with normal RAC-positive or abnormal RAC-negative mucosal patterns. Helicobacter pylori status was established by hematoxylin and eosin staining and immunohistochemistry. RESULTS: 41 RAC-positive and 124 RAC-negative patients were enrolled from June 2020 to September 2020. The prevalence of H. pylori infection in patients with RAC-positive pattern and RAC-negative pattern was 7.3% (3/41) and 71.0% (88/124), respectively. Among all 124 RAC-negative patients, 36 (29.0%) patients were H. pylori-negative status. Ten patients (32.3%) demonstrated RAC-positive pattern in 31 H. pylori-eradicated cases. The sensitivity, specificity, positive predictive value, and negative predictive value of RAC-positive pattern for predicting H. pylori-negative status were 51.4% (95% CI, 0.395–0.630), 96.7% (95% CI, 0.900–0.991), 92.7% (95% CI, 0.790–0.981), and 71.0% (95% CI, 0.620–0.786), respectively. CONCLUSIONS: RAC presence can accurately rule out H. pylori infection of gastric corpus, and H. pylori-positive status cannot be predicted only by RAC absence in routine endoscopy. Trial registration The present study is a non-interventional trial.
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spelling pubmed-85276062021-10-25 Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy Yuan, Cong Lin, Xue-Mei Ou, Yan Cai, Lin Cheng, Qian Zhou, Ping Liao, Juan BMC Gastroenterol Research BACKGROUND: The sensitivity of regular arrangement of collecting venules (RAC)-positive pattern for predicting Helicobacter pylori (H. pylori)-negative status greatly altered from 93.8 to 48.0% in recent two decades of various studies, while the reason behind it remained obscure. The aim of this study was to investigate the value of RAC as an endoscopic feature for judging H. pylori status in routine endoscopy and reviewed the underlying mechanism. METHODS: A prospective study with high-definition non-magnifying endoscopy was performed. RAC-positive and RAC-negative patients were classified according to the collecting venules morphology of the lesser curvature in gastric corpus. Gastric biopsy specimens were obtained from the lesser and greater curvature of corpus with normal RAC-positive or abnormal RAC-negative mucosal patterns. Helicobacter pylori status was established by hematoxylin and eosin staining and immunohistochemistry. RESULTS: 41 RAC-positive and 124 RAC-negative patients were enrolled from June 2020 to September 2020. The prevalence of H. pylori infection in patients with RAC-positive pattern and RAC-negative pattern was 7.3% (3/41) and 71.0% (88/124), respectively. Among all 124 RAC-negative patients, 36 (29.0%) patients were H. pylori-negative status. Ten patients (32.3%) demonstrated RAC-positive pattern in 31 H. pylori-eradicated cases. The sensitivity, specificity, positive predictive value, and negative predictive value of RAC-positive pattern for predicting H. pylori-negative status were 51.4% (95% CI, 0.395–0.630), 96.7% (95% CI, 0.900–0.991), 92.7% (95% CI, 0.790–0.981), and 71.0% (95% CI, 0.620–0.786), respectively. CONCLUSIONS: RAC presence can accurately rule out H. pylori infection of gastric corpus, and H. pylori-positive status cannot be predicted only by RAC absence in routine endoscopy. Trial registration The present study is a non-interventional trial. BioMed Central 2021-10-20 /pmc/articles/PMC8527606/ /pubmed/34670510 http://dx.doi.org/10.1186/s12876-021-01960-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yuan, Cong
Lin, Xue-Mei
Ou, Yan
Cai, Lin
Cheng, Qian
Zhou, Ping
Liao, Juan
Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy
title Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy
title_full Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy
title_fullStr Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy
title_full_unstemmed Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy
title_short Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy
title_sort association between regular arrangement of collecting venules and helicobacter pylori status in routine endoscopy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527606/
https://www.ncbi.nlm.nih.gov/pubmed/34670510
http://dx.doi.org/10.1186/s12876-021-01960-w
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