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Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections
OBJECTIVE: The goal of this study was to monitor the compliance and impact on a protocol change of surgical antimicrobial prophylaxis in cardiac surgery favouring cefazolin instead cefuroxime, initiated by the hospital’s antimicrobial stewardship team. METHODS: This quality improvement study was per...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527641/ https://www.ncbi.nlm.nih.gov/pubmed/34670594 http://dx.doi.org/10.1186/s13019-021-01693-7 |
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author | Surat, Güzin Bernsen, Dominik Schimmer, Christoph |
author_facet | Surat, Güzin Bernsen, Dominik Schimmer, Christoph |
author_sort | Surat, Güzin |
collection | PubMed |
description | OBJECTIVE: The goal of this study was to monitor the compliance and impact on a protocol change of surgical antimicrobial prophylaxis in cardiac surgery favouring cefazolin instead cefuroxime, initiated by the hospital’s antimicrobial stewardship team. METHODS: This quality improvement study was performed in a tertiary care hospital in collaboration with the department of cardiothoracic surgery and the hospitals antimicrobial stewardship team following a revision of the standard for surgical antimicrobial prophylaxis including 1029 patients who underwent cardiac surgery. 582 patients receiving cefuroxime and 447 patients receiving cefazolin respectively were compared without altering any other preventative perioperative measures including its postoperative duration of less than 24 h. Adherence and surgical site infections were compiled and analysed. RESULTS: A complete adherence was achieved. Overall surgical site infections occurred in 37 (3.6%) of the cases, 20 (3.4%) in cefuroxime patients and 17 (3.8%) in cefazolin patients (p value = 0.754). No statistically significant differences could be found in any of the primary endpoints, but there was a trend towards less deep sternal wound infections in the cefazolin group. CONCLUSIONS: The study supports the role of antimicrobial stewardship in cardiac surgery and mirrors the success of a multidisciplinary team aiming to minimize adverse events by optimizing antibiotic use. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-021-01693-7. |
format | Online Article Text |
id | pubmed-8527641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85276412021-10-25 Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections Surat, Güzin Bernsen, Dominik Schimmer, Christoph J Cardiothorac Surg Research Article OBJECTIVE: The goal of this study was to monitor the compliance and impact on a protocol change of surgical antimicrobial prophylaxis in cardiac surgery favouring cefazolin instead cefuroxime, initiated by the hospital’s antimicrobial stewardship team. METHODS: This quality improvement study was performed in a tertiary care hospital in collaboration with the department of cardiothoracic surgery and the hospitals antimicrobial stewardship team following a revision of the standard for surgical antimicrobial prophylaxis including 1029 patients who underwent cardiac surgery. 582 patients receiving cefuroxime and 447 patients receiving cefazolin respectively were compared without altering any other preventative perioperative measures including its postoperative duration of less than 24 h. Adherence and surgical site infections were compiled and analysed. RESULTS: A complete adherence was achieved. Overall surgical site infections occurred in 37 (3.6%) of the cases, 20 (3.4%) in cefuroxime patients and 17 (3.8%) in cefazolin patients (p value = 0.754). No statistically significant differences could be found in any of the primary endpoints, but there was a trend towards less deep sternal wound infections in the cefazolin group. CONCLUSIONS: The study supports the role of antimicrobial stewardship in cardiac surgery and mirrors the success of a multidisciplinary team aiming to minimize adverse events by optimizing antibiotic use. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-021-01693-7. BioMed Central 2021-10-20 /pmc/articles/PMC8527641/ /pubmed/34670594 http://dx.doi.org/10.1186/s13019-021-01693-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Surat, Güzin Bernsen, Dominik Schimmer, Christoph Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections |
title | Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections |
title_full | Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections |
title_fullStr | Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections |
title_full_unstemmed | Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections |
title_short | Antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections |
title_sort | antimicrobial stewardship measures in cardiac surgery and its impact on surgical site infections |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527641/ https://www.ncbi.nlm.nih.gov/pubmed/34670594 http://dx.doi.org/10.1186/s13019-021-01693-7 |
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