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Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527819/ https://www.ncbi.nlm.nih.gov/pubmed/34669097 http://dx.doi.org/10.1007/s12012-021-09700-y |
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author | Nikdoust, Farahnaz Pazoki, Mahboubeh Mohammadtaghizadeh, Mohammadjavad Aghaali, Mahsa Karimzadeh Amrovani, Mehran |
author_facet | Nikdoust, Farahnaz Pazoki, Mahboubeh Mohammadtaghizadeh, Mohammadjavad Aghaali, Mahsa Karimzadeh Amrovani, Mehran |
author_sort | Nikdoust, Farahnaz |
collection | PubMed |
description | Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress and apoptosis, which can be effective in endothelial dysfunction. Due to the induction of mentioned processes in the endothelial cells, the intercellular connections are destroyed, cell permeability increases and finally cell efficiency decreases and functional defects occur. Cardiovascular disease (CVDs) are of consequences of endothelial dysfunction. Thus by identifying the exosome signaling pathways, which induce inflammation, oxidative stress, and apoptosis, endothelial dysfunction and subsequently CVDs can be reduced; exosomes can be used for appropriate target therapy. |
format | Online Article Text |
id | pubmed-8527819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-85278192021-10-21 Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease Nikdoust, Farahnaz Pazoki, Mahboubeh Mohammadtaghizadeh, Mohammadjavad Aghaali, Mahsa Karimzadeh Amrovani, Mehran Cardiovasc Toxicol Article Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress and apoptosis, which can be effective in endothelial dysfunction. Due to the induction of mentioned processes in the endothelial cells, the intercellular connections are destroyed, cell permeability increases and finally cell efficiency decreases and functional defects occur. Cardiovascular disease (CVDs) are of consequences of endothelial dysfunction. Thus by identifying the exosome signaling pathways, which induce inflammation, oxidative stress, and apoptosis, endothelial dysfunction and subsequently CVDs can be reduced; exosomes can be used for appropriate target therapy. Springer US 2021-10-20 2022 /pmc/articles/PMC8527819/ /pubmed/34669097 http://dx.doi.org/10.1007/s12012-021-09700-y Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Nikdoust, Farahnaz Pazoki, Mahboubeh Mohammadtaghizadeh, Mohammadjavad Aghaali, Mahsa Karimzadeh Amrovani, Mehran Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease |
title | Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease |
title_full | Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease |
title_fullStr | Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease |
title_full_unstemmed | Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease |
title_short | Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease |
title_sort | exosomes: potential player in endothelial dysfunction in cardiovascular disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527819/ https://www.ncbi.nlm.nih.gov/pubmed/34669097 http://dx.doi.org/10.1007/s12012-021-09700-y |
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