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Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease

Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress...

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Autores principales: Nikdoust, Farahnaz, Pazoki, Mahboubeh, Mohammadtaghizadeh, Mohammadjavad, Aghaali, Mahsa Karimzadeh, Amrovani, Mehran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527819/
https://www.ncbi.nlm.nih.gov/pubmed/34669097
http://dx.doi.org/10.1007/s12012-021-09700-y
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author Nikdoust, Farahnaz
Pazoki, Mahboubeh
Mohammadtaghizadeh, Mohammadjavad
Aghaali, Mahsa Karimzadeh
Amrovani, Mehran
author_facet Nikdoust, Farahnaz
Pazoki, Mahboubeh
Mohammadtaghizadeh, Mohammadjavad
Aghaali, Mahsa Karimzadeh
Amrovani, Mehran
author_sort Nikdoust, Farahnaz
collection PubMed
description Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress and apoptosis, which can be effective in endothelial dysfunction. Due to the induction of mentioned processes in the endothelial cells, the intercellular connections are destroyed, cell permeability increases and finally cell efficiency decreases and functional defects occur. Cardiovascular disease (CVDs) are of consequences of endothelial dysfunction. Thus by identifying the exosome signaling pathways, which induce inflammation, oxidative stress, and apoptosis, endothelial dysfunction and subsequently CVDs can be reduced; exosomes can be used for appropriate target therapy.
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spelling pubmed-85278192021-10-21 Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease Nikdoust, Farahnaz Pazoki, Mahboubeh Mohammadtaghizadeh, Mohammadjavad Aghaali, Mahsa Karimzadeh Amrovani, Mehran Cardiovasc Toxicol Article Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress and apoptosis, which can be effective in endothelial dysfunction. Due to the induction of mentioned processes in the endothelial cells, the intercellular connections are destroyed, cell permeability increases and finally cell efficiency decreases and functional defects occur. Cardiovascular disease (CVDs) are of consequences of endothelial dysfunction. Thus by identifying the exosome signaling pathways, which induce inflammation, oxidative stress, and apoptosis, endothelial dysfunction and subsequently CVDs can be reduced; exosomes can be used for appropriate target therapy. Springer US 2021-10-20 2022 /pmc/articles/PMC8527819/ /pubmed/34669097 http://dx.doi.org/10.1007/s12012-021-09700-y Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Nikdoust, Farahnaz
Pazoki, Mahboubeh
Mohammadtaghizadeh, Mohammadjavad
Aghaali, Mahsa Karimzadeh
Amrovani, Mehran
Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
title Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
title_full Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
title_fullStr Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
title_full_unstemmed Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
title_short Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
title_sort exosomes: potential player in endothelial dysfunction in cardiovascular disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527819/
https://www.ncbi.nlm.nih.gov/pubmed/34669097
http://dx.doi.org/10.1007/s12012-021-09700-y
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