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Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern recognition receptor ligation and activation of inflammatory pathways. Here, we studied how microglia handle and cope with α-synuclein (α-syn) fibrils and their clearance. We found that microglia exposed to...

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Detalles Bibliográficos
Autores principales:	Scheiblich, Hannah, Dansokho, Cira, Mercan, Dilek, Schmidt, Susanne V., Bousset, Luc, Wischhof, Lena, Eikens, Frederik, Odainic, Alexandru, Spitzer, Jasper, Griep, Angelika, Schwartz, Stephanie, Bano, Daniele, Latz, Eicke, Melki, Ronald, Heneka, Michael T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527836/ https://www.ncbi.nlm.nih.gov/pubmed/34555357 http://dx.doi.org/10.1016/j.cell.2021.09.007

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