Interferon-Gamma–Producing CD8(+) Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis

BACKGROUND & AIMS: The pathogenesis of immune checkpoint inhibitor (ICI)–colitis remains incompletely understood. We sought to identify key cellular drivers of ICI-colitis and their similarities to idiopathic ulcerative colitis, and to determine potential novel therapeutic targets. METHODS: We u...

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Detalles Bibliográficos
Autores principales: Sasson, Sarah C., Slevin, Stephanie M., Cheung, Vincent T.F., Nassiri, Isar, Olsson-Brown, Anna, Fryer, Eve, Ferreira, Ricardo C., Trzupek, Dominik, Gupta, Tarun, Al-Hillawi, Lulia, Issaias, Mari-lenna, Easton, Alistair, Campo, Leticia, FitzPatrick, Michael E.B., Adams, Joss, Chitnis, Meenali, Protheroe, Andrew, Tuthill, Mark, Coupe, Nicholas, Simmons, Alison, Payne, Miranda, Middleton, Mark R., Travis, Simon P.L., Fairfax, Benjamin P., Klenerman, Paul, Brain, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527886/
https://www.ncbi.nlm.nih.gov/pubmed/34147519
http://dx.doi.org/10.1053/j.gastro.2021.06.025

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