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Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article

Alzheimer’s disease (AD) is characterized by the excessive deposition of extracellular amyloid-beta peptide (Aβ) and the build-up of intracellular neurofibrillary tangles containing hyperphosphorylated tau proteins. This leads to neuronal damage, cell death and consequently results in memory and lea...

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Autores principales: Rezaee, Nasim, Fernando, W.M.A.D. Binosha, Hone, Eugene, Sohrabi, Hamid R., Johnson, Stuart K., Gunzburg, Stuart, Martins, Ralph N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527926/
https://www.ncbi.nlm.nih.gov/pubmed/34690742
http://dx.doi.org/10.3389/fnagi.2021.729949
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author Rezaee, Nasim
Fernando, W.M.A.D. Binosha
Hone, Eugene
Sohrabi, Hamid R.
Johnson, Stuart K.
Gunzburg, Stuart
Martins, Ralph N.
author_facet Rezaee, Nasim
Fernando, W.M.A.D. Binosha
Hone, Eugene
Sohrabi, Hamid R.
Johnson, Stuart K.
Gunzburg, Stuart
Martins, Ralph N.
author_sort Rezaee, Nasim
collection PubMed
description Alzheimer’s disease (AD) is characterized by the excessive deposition of extracellular amyloid-beta peptide (Aβ) and the build-up of intracellular neurofibrillary tangles containing hyperphosphorylated tau proteins. This leads to neuronal damage, cell death and consequently results in memory and learning impairments leading to dementia. Although the exact cause of AD is not yet clear, numerous studies indicate that oxidative stress, inflammation, and mitochondrial dysfunction significantly contribute to its onset and progression. There is no effective therapeutic approach to stop the progression of AD and its associated symptoms. Thus, early intervention, preferably, pre-clinically when the brain is not significantly affected, is a better option for effective treatment. Natural polyphenols (PP) target multiple AD-related pathways such as protecting the brain from Aβ and tau neurotoxicity, ameliorating oxidative damage and mitochondrial dysfunction. Among natural products, the cereal crop sorghum has some unique features. It is one of the major global grain crops but in the developed world, it is primarily used as feed for farm animals. A broad range of PP, including phenolic acids, flavonoids, and condensed tannins are present in sorghum grain including some classes such as proanthocyanidins that are rarely found in others plants. Pigmented varieties of sorghum have the highest polyphenolic content and antioxidant activity which potentially makes their consumption beneficial for human health through different pathways such as oxidative stress reduction and thus the prevention and treatment of neurodegenerative diseases. This review summarizes the potential of sorghum PP to beneficially affect the neuropathology of AD.
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spelling pubmed-85279262021-10-21 Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article Rezaee, Nasim Fernando, W.M.A.D. Binosha Hone, Eugene Sohrabi, Hamid R. Johnson, Stuart K. Gunzburg, Stuart Martins, Ralph N. Front Aging Neurosci Neuroscience Alzheimer’s disease (AD) is characterized by the excessive deposition of extracellular amyloid-beta peptide (Aβ) and the build-up of intracellular neurofibrillary tangles containing hyperphosphorylated tau proteins. This leads to neuronal damage, cell death and consequently results in memory and learning impairments leading to dementia. Although the exact cause of AD is not yet clear, numerous studies indicate that oxidative stress, inflammation, and mitochondrial dysfunction significantly contribute to its onset and progression. There is no effective therapeutic approach to stop the progression of AD and its associated symptoms. Thus, early intervention, preferably, pre-clinically when the brain is not significantly affected, is a better option for effective treatment. Natural polyphenols (PP) target multiple AD-related pathways such as protecting the brain from Aβ and tau neurotoxicity, ameliorating oxidative damage and mitochondrial dysfunction. Among natural products, the cereal crop sorghum has some unique features. It is one of the major global grain crops but in the developed world, it is primarily used as feed for farm animals. A broad range of PP, including phenolic acids, flavonoids, and condensed tannins are present in sorghum grain including some classes such as proanthocyanidins that are rarely found in others plants. Pigmented varieties of sorghum have the highest polyphenolic content and antioxidant activity which potentially makes their consumption beneficial for human health through different pathways such as oxidative stress reduction and thus the prevention and treatment of neurodegenerative diseases. This review summarizes the potential of sorghum PP to beneficially affect the neuropathology of AD. Frontiers Media S.A. 2021-10-06 /pmc/articles/PMC8527926/ /pubmed/34690742 http://dx.doi.org/10.3389/fnagi.2021.729949 Text en Copyright © 2021 Rezaee, Fernando, Hone, Sohrabi, Johnson, Gunzburg and Martins. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rezaee, Nasim
Fernando, W.M.A.D. Binosha
Hone, Eugene
Sohrabi, Hamid R.
Johnson, Stuart K.
Gunzburg, Stuart
Martins, Ralph N.
Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
title Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
title_full Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
title_fullStr Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
title_full_unstemmed Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
title_short Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
title_sort potential of sorghum polyphenols to prevent and treat alzheimer’s disease: a review article
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527926/
https://www.ncbi.nlm.nih.gov/pubmed/34690742
http://dx.doi.org/10.3389/fnagi.2021.729949
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