Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

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Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures effective against SARS-CoV-2 variants and future spillovers of other sarbecoviruses. Here we describe the isolation and characterization of a human monoclonal antibody, designated S2K146, broadly...

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Detalles Bibliográficos
Autores principales: Park, Young-Jun, De Marco, Anna, Starr, Tyler N, Liu, Zhuoming, Pinto, Dora, Walls, Alexandra C., Zatta, Fabrizia, Zepeda, Samantha K., Bowen, John, Sprouse, Kaitlin S, Joshi, Anshu, Giurdanella, Martina, Guarino, Barbara, Noack, Julia, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Lempp, Florian A., Benigni, Fabio, Snell, Gyorgy, Neyts, Johan, Whelan, Sean PJ, Virgin, Herbert W., Bloom, Jesse D, Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528076/
https://www.ncbi.nlm.nih.gov/pubmed/34671770
http://dx.doi.org/10.1101/2021.10.13.464254
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