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Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques w...

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Autores principales: Leitgeb, Rainer, Placzek, Fabian, Rank, Elisabet, Krainz, Lisa, Haindl, Richard, Li, Qian, Liu, Mengyang, Andreana, Marco, Unterhuber, Angelika, Schmoll, Tilman, Drexler, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528212/
https://www.ncbi.nlm.nih.gov/pubmed/34672145
http://dx.doi.org/10.1117/1.JBO.26.10.100601
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author Leitgeb, Rainer
Placzek, Fabian
Rank, Elisabet
Krainz, Lisa
Haindl, Richard
Li, Qian
Liu, Mengyang
Andreana, Marco
Unterhuber, Angelika
Schmoll, Tilman
Drexler, Wolfgang
author_facet Leitgeb, Rainer
Placzek, Fabian
Rank, Elisabet
Krainz, Lisa
Haindl, Richard
Li, Qian
Liu, Mengyang
Andreana, Marco
Unterhuber, Angelika
Schmoll, Tilman
Drexler, Wolfgang
author_sort Leitgeb, Rainer
collection PubMed
description Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance. Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis. Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results: The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential. Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential—in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.
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spelling pubmed-85282122021-10-22 Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography Leitgeb, Rainer Placzek, Fabian Rank, Elisabet Krainz, Lisa Haindl, Richard Li, Qian Liu, Mengyang Andreana, Marco Unterhuber, Angelika Schmoll, Tilman Drexler, Wolfgang J Biomed Opt Perspectives Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance. Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis. Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results: The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential. Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential—in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision. Society of Photo-Optical Instrumentation Engineers 2021-10-20 2021-10 /pmc/articles/PMC8528212/ /pubmed/34672145 http://dx.doi.org/10.1117/1.JBO.26.10.100601 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Perspectives
Leitgeb, Rainer
Placzek, Fabian
Rank, Elisabet
Krainz, Lisa
Haindl, Richard
Li, Qian
Liu, Mengyang
Andreana, Marco
Unterhuber, Angelika
Schmoll, Tilman
Drexler, Wolfgang
Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
title Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
title_full Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
title_fullStr Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
title_full_unstemmed Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
title_short Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
title_sort enhanced medical diagnosis for doctors: a perspective of optical coherence tomography
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528212/
https://www.ncbi.nlm.nih.gov/pubmed/34672145
http://dx.doi.org/10.1117/1.JBO.26.10.100601
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