The SMAC mimetic AT-101 exhibits anti-tumor and anti-metastasis activity in lung adenocarcinoma cells by the IAPs/ caspase-dependent apoptosis and p65-NFƙB cross-talk

OBJECTIVE(S): The Inhibitors of Apoptosis (IAPs) regulate initiator and effector phases of caspase mediated apoptosis. This study evaluates the effects of SMAC mimetic AT-101 in regulation of IAPs/caspases/NFƙB-p65 in an adenocarcinoma cell line. MATERIALS AND METHODS: MTT assay was performed in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmad, Irfan, Irfan, Safia, Ali Beg, Mirza Masroor, Kamli, Hossam, Ali, Syed Parveen, Begum, Naseem, Alshahrani, Mohammad Y, Rajagopalan, Prasanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528260/
https://www.ncbi.nlm.nih.gov/pubmed/34712428
http://dx.doi.org/10.22038/ijbms.2021.56400.12586

Ejemplares similares

Ejemplares similares