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Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors
BACKGROUND: Localization of tumors to the brainstem carries a poor prognosis, however, risk factors are poorly understood. We examined secular trends in mortality from brainstem tumors in the United States by age, sex, and race/ethnicity. METHODS: We extracted age-adjusted incidence-based mortality...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528263/ https://www.ncbi.nlm.nih.gov/pubmed/34693287 http://dx.doi.org/10.1093/noajnl/vdab137 |
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author | Tomita, Yusuke Tanaka, Yoshihiro Takata, Nozomu Hibler, Elizabeth A Hashizume, Rintaro Becher, Oren Josh |
author_facet | Tomita, Yusuke Tanaka, Yoshihiro Takata, Nozomu Hibler, Elizabeth A Hashizume, Rintaro Becher, Oren Josh |
author_sort | Tomita, Yusuke |
collection | PubMed |
description | BACKGROUND: Localization of tumors to the brainstem carries a poor prognosis, however, risk factors are poorly understood. We examined secular trends in mortality from brainstem tumors in the United States by age, sex, and race/ethnicity. METHODS: We extracted age-adjusted incidence-based mortality rates of brainstem tumors from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2018. Trends in age-adjusted mortality rate (AAMR) were compared by sex and race/ethnicity among the younger age group (0-14 years) and the older age group (>15 years), respectively. Average AAMRs in each 5-year age group were compared by sex. RESULTS: This study included 2039 brainstem tumor-related deaths between 2004 and 2018. Trends in AAMRs were constant during the study period in both age groups, with 3 times higher AAMR in the younger age group compared to the older age group. Males had a significantly higher AAMR in the older age group, while no racial differences were observed. Intriguingly, AAMRs peaked in patients 5-9 years of age (0.57 per 100 000) and in patients 80-84 years of age (0.31 per 100 000), with lower rates among middle-aged individuals. Among 5-9 years of age, the average AAMR for females was significantly higher than that of males (P = .017), whereas the reverse trend was seen among those 50-79 years of age. CONCLUSIONS: Overall trends in AAMRs for brainstem tumors were constant during the study period with significant differences by age and sex. Identifying the biological mechanisms of demographic differences in AAMR may help understand this fatal pathology. |
format | Online Article Text |
id | pubmed-8528263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-85282632021-10-21 Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors Tomita, Yusuke Tanaka, Yoshihiro Takata, Nozomu Hibler, Elizabeth A Hashizume, Rintaro Becher, Oren Josh Neurooncol Adv Clinical Investigations BACKGROUND: Localization of tumors to the brainstem carries a poor prognosis, however, risk factors are poorly understood. We examined secular trends in mortality from brainstem tumors in the United States by age, sex, and race/ethnicity. METHODS: We extracted age-adjusted incidence-based mortality rates of brainstem tumors from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2018. Trends in age-adjusted mortality rate (AAMR) were compared by sex and race/ethnicity among the younger age group (0-14 years) and the older age group (>15 years), respectively. Average AAMRs in each 5-year age group were compared by sex. RESULTS: This study included 2039 brainstem tumor-related deaths between 2004 and 2018. Trends in AAMRs were constant during the study period in both age groups, with 3 times higher AAMR in the younger age group compared to the older age group. Males had a significantly higher AAMR in the older age group, while no racial differences were observed. Intriguingly, AAMRs peaked in patients 5-9 years of age (0.57 per 100 000) and in patients 80-84 years of age (0.31 per 100 000), with lower rates among middle-aged individuals. Among 5-9 years of age, the average AAMR for females was significantly higher than that of males (P = .017), whereas the reverse trend was seen among those 50-79 years of age. CONCLUSIONS: Overall trends in AAMRs for brainstem tumors were constant during the study period with significant differences by age and sex. Identifying the biological mechanisms of demographic differences in AAMR may help understand this fatal pathology. Oxford University Press 2021-09-17 /pmc/articles/PMC8528263/ /pubmed/34693287 http://dx.doi.org/10.1093/noajnl/vdab137 Text en © The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigations Tomita, Yusuke Tanaka, Yoshihiro Takata, Nozomu Hibler, Elizabeth A Hashizume, Rintaro Becher, Oren Josh Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors |
title | Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors |
title_full | Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors |
title_fullStr | Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors |
title_full_unstemmed | Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors |
title_short | Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors |
title_sort | fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors |
topic | Clinical Investigations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528263/ https://www.ncbi.nlm.nih.gov/pubmed/34693287 http://dx.doi.org/10.1093/noajnl/vdab137 |
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