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Treatment of oral chronic graft-versus-host disease: a retrospective cohort study

OBJECTIVE: The aim of this study was to evaluate patients with complete response of oral chronic graft-versus-host disease to immunosuppressive treatment. METHODS: A total of 29 patients submitted to allogeneic hematopoietic stem cell transplantation, with oral chronic graft-versus-host disease, wer...

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Autores principales: Ramos, Gabriela de Assis, Leite, Taísa Domingues Boehmer, Lobo, Camila Brandão, Santos, Paulo Sérgio da Silva, Moreira, Maria Claudia Rodrigues, Antunes, Héliton Spindola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528385/
https://www.ncbi.nlm.nih.gov/pubmed/34730704
http://dx.doi.org/10.31744/einstein_journal/2021AO6177
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author Ramos, Gabriela de Assis
Leite, Taísa Domingues Boehmer
Lobo, Camila Brandão
Santos, Paulo Sérgio da Silva
Moreira, Maria Claudia Rodrigues
Antunes, Héliton Spindola
author_facet Ramos, Gabriela de Assis
Leite, Taísa Domingues Boehmer
Lobo, Camila Brandão
Santos, Paulo Sérgio da Silva
Moreira, Maria Claudia Rodrigues
Antunes, Héliton Spindola
author_sort Ramos, Gabriela de Assis
collection PubMed
description OBJECTIVE: The aim of this study was to evaluate patients with complete response of oral chronic graft-versus-host disease to immunosuppressive treatment. METHODS: A total of 29 patients submitted to allogeneic hematopoietic stem cell transplantation, with oral chronic graft-versus-host disease, were enrolled in this retrospective study, from September 2012 to February 2018. Patients were treated with combined topical dexamethasone solution and topical tacrolimus ointment, combined topical dexamethasone and topical tacrolimus, systemic immunosuppressive medication, and topical dexamethasone only. RESULTS: The mean time of complete response of lichenoid lesions, erythema, and ulcers using dexamethasone and systemic immunosuppressive medication was of 105, 42 and 42 days, respectively (p=0.013).When we associated dexamethasone, tacrolimus and systemic immunosuppressive medication, the mean time of complete response of lichenoid lesions, erythema and ulcers was of 91,84 and 77 days (p=0.011). When dexamethasone was used alone, the mean time of complete response of lichenoid lesions, erythema and ulcers was 182, 140, 21 days, respectively (p=0.042). CONCLUSION: Our study shows that lichenoid lesions require more time to heal. Notably, lichenoid lesions tend to respond better to dexamethasone combined with tacrolimus and systemic immunosuppressive medication, whereas erythema and ulcers respond better to dexamethasone combined with systemic immunosuppressive medication and dexamethasone only, respectively.
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spelling pubmed-85283852021-10-22 Treatment of oral chronic graft-versus-host disease: a retrospective cohort study Ramos, Gabriela de Assis Leite, Taísa Domingues Boehmer Lobo, Camila Brandão Santos, Paulo Sérgio da Silva Moreira, Maria Claudia Rodrigues Antunes, Héliton Spindola Einstein (Sao Paulo) Original Article OBJECTIVE: The aim of this study was to evaluate patients with complete response of oral chronic graft-versus-host disease to immunosuppressive treatment. METHODS: A total of 29 patients submitted to allogeneic hematopoietic stem cell transplantation, with oral chronic graft-versus-host disease, were enrolled in this retrospective study, from September 2012 to February 2018. Patients were treated with combined topical dexamethasone solution and topical tacrolimus ointment, combined topical dexamethasone and topical tacrolimus, systemic immunosuppressive medication, and topical dexamethasone only. RESULTS: The mean time of complete response of lichenoid lesions, erythema, and ulcers using dexamethasone and systemic immunosuppressive medication was of 105, 42 and 42 days, respectively (p=0.013).When we associated dexamethasone, tacrolimus and systemic immunosuppressive medication, the mean time of complete response of lichenoid lesions, erythema and ulcers was of 91,84 and 77 days (p=0.011). When dexamethasone was used alone, the mean time of complete response of lichenoid lesions, erythema and ulcers was 182, 140, 21 days, respectively (p=0.042). CONCLUSION: Our study shows that lichenoid lesions require more time to heal. Notably, lichenoid lesions tend to respond better to dexamethasone combined with tacrolimus and systemic immunosuppressive medication, whereas erythema and ulcers respond better to dexamethasone combined with systemic immunosuppressive medication and dexamethasone only, respectively. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2021-10-20 /pmc/articles/PMC8528385/ /pubmed/34730704 http://dx.doi.org/10.31744/einstein_journal/2021AO6177 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ramos, Gabriela de Assis
Leite, Taísa Domingues Boehmer
Lobo, Camila Brandão
Santos, Paulo Sérgio da Silva
Moreira, Maria Claudia Rodrigues
Antunes, Héliton Spindola
Treatment of oral chronic graft-versus-host disease: a retrospective cohort study
title Treatment of oral chronic graft-versus-host disease: a retrospective cohort study
title_full Treatment of oral chronic graft-versus-host disease: a retrospective cohort study
title_fullStr Treatment of oral chronic graft-versus-host disease: a retrospective cohort study
title_full_unstemmed Treatment of oral chronic graft-versus-host disease: a retrospective cohort study
title_short Treatment of oral chronic graft-versus-host disease: a retrospective cohort study
title_sort treatment of oral chronic graft-versus-host disease: a retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528385/
https://www.ncbi.nlm.nih.gov/pubmed/34730704
http://dx.doi.org/10.31744/einstein_journal/2021AO6177
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