Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing

Addictive drugs increase dopamine in the nucleus accumbens (NAc), where it persistently shapes excitatory glutamate transmission and hijacks natural reward processing. Here, we provide evidence, from mice to humans, that an underlying mechanism relies on drug-evoked heteromerization of glutamate N-m...

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Detalles Bibliográficos
Autores principales: Andrianarivelo, Andry, Saint-Jour, Estefani, Pousinha, Paula, Fernandez, Sebastian P., Petitbon, Anna, De Smedt-Peyrusse, Veronique, Heck, Nicolas, Ortiz, Vanesa, Allichon, Marie-Charlotte, Kappès, Vincent, Betuing, Sandrine, Walle, Roman, Zhu, Ying, Joséphine, Charlène, Bemelmans, Alexis-Pierre, Turecki, Gustavo, Mechawar, Naguib, Javitch, Jonathan A., Caboche, Jocelyne, Trifilieff, Pierre, Barik, Jacques, Vanhoutte, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528421/
https://www.ncbi.nlm.nih.gov/pubmed/34669474
http://dx.doi.org/10.1126/sciadv.abg5970

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