Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension

Cancer therapies are being considered for treating rare noncancerous diseases like pulmonary hypertension (PH), but effective computational screening is lacking. Via transcriptomic differential dependency analyses leveraging parallels between cancer and PH, we mapped a landscape of cancer drug funct...

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Detalles Bibliográficos
Autores principales: Negi, Vinny, Yang, Jimin, Speyer, Gil, Pulgarin, Andres, Handen, Adam, Zhao, Jingsi, Tai, Yi Yin, Tang, Ying, Culley, Miranda K., Yu, Qiujun, Forsythe, Patricia, Gorelova, Anastasia, Watson, Annie M., Al Aaraj, Yassmin, Satoh, Taijyu, Sharifi-Sanjani, Maryam, Rajaratnam, Arun, Sembrat, John, Provencher, Steeve, Yin, Xianglin, Vargas, Sara O., Rojas, Mauricio, Bonnet, Sébastien, Torrino, Stephanie, Wagner, Bridget K., Schreiber, Stuart L., Dai, Mingji, Bertero, Thomas, Al Ghouleh, Imad, Kim, Seungchan, Chan, Stephen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528428/
https://www.ncbi.nlm.nih.gov/pubmed/34669463
http://dx.doi.org/10.1126/sciadv.abh3794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528428/
https://www.ncbi.nlm.nih.gov/pubmed/34669463
http://dx.doi.org/10.1126/sciadv.abh3794

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