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Disease progression in Parkinson‘s disease patients with subjective cognitive complaint
OBJECTIVE: Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528458/ https://www.ncbi.nlm.nih.gov/pubmed/34595848 http://dx.doi.org/10.1002/acn3.51461 |
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author | Han, Lin‐Lin Wang, Lan Xu, Zhi‐Heng Liang, Xiao‐Niu Zhang, Meng‐Wei Fan, Yun Sun, Yi‐Min Liu, Feng‐Tao Yu, Wen‐Bo Tang, Yi‐Lin |
author_facet | Han, Lin‐Lin Wang, Lan Xu, Zhi‐Heng Liang, Xiao‐Niu Zhang, Meng‐Wei Fan, Yun Sun, Yi‐Min Liu, Feng‐Tao Yu, Wen‐Bo Tang, Yi‐Lin |
author_sort | Han, Lin‐Lin |
collection | PubMed |
description | OBJECTIVE: Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI). METHODS: A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD. RESULTS: At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p < 0.05). Longitudinal analyses revealed that the PD‐SCC group exhibited faster progression in terms of BDI scores (p = 0.042) and PDQ‐39 scores (p = 0.035) than the PD‐NC group. The PD‐MCI group exhibited faster progression rates in the Epworth Sleepiness Scale scores (p = 0.001) and PDQ‐39 scores (p = 0.005) than the PD‐NC group. In addition, the PD‐SCC group exhibited a greater reduction in attention (Trail Making Test Part A, p = 0.047) and executive function (Stroop Color‐Word Test, p = 0.037) than the PD‐NC group. INTERPRETATION: PD‐SCC patients exhibited faster deterioration of depression and QoL than PD‐NC patients, and SCC may be an indicator of initial attention and executive function decline in PD. Our findings provided a more accurate prognosis in PD‐SCC patients. |
format | Online Article Text |
id | pubmed-8528458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85284582021-10-27 Disease progression in Parkinson‘s disease patients with subjective cognitive complaint Han, Lin‐Lin Wang, Lan Xu, Zhi‐Heng Liang, Xiao‐Niu Zhang, Meng‐Wei Fan, Yun Sun, Yi‐Min Liu, Feng‐Tao Yu, Wen‐Bo Tang, Yi‐Lin Ann Clin Transl Neurol Research Article OBJECTIVE: Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI). METHODS: A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD. RESULTS: At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p < 0.05). Longitudinal analyses revealed that the PD‐SCC group exhibited faster progression in terms of BDI scores (p = 0.042) and PDQ‐39 scores (p = 0.035) than the PD‐NC group. The PD‐MCI group exhibited faster progression rates in the Epworth Sleepiness Scale scores (p = 0.001) and PDQ‐39 scores (p = 0.005) than the PD‐NC group. In addition, the PD‐SCC group exhibited a greater reduction in attention (Trail Making Test Part A, p = 0.047) and executive function (Stroop Color‐Word Test, p = 0.037) than the PD‐NC group. INTERPRETATION: PD‐SCC patients exhibited faster deterioration of depression and QoL than PD‐NC patients, and SCC may be an indicator of initial attention and executive function decline in PD. Our findings provided a more accurate prognosis in PD‐SCC patients. John Wiley and Sons Inc. 2021-09-30 /pmc/articles/PMC8528458/ /pubmed/34595848 http://dx.doi.org/10.1002/acn3.51461 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Article Han, Lin‐Lin Wang, Lan Xu, Zhi‐Heng Liang, Xiao‐Niu Zhang, Meng‐Wei Fan, Yun Sun, Yi‐Min Liu, Feng‐Tao Yu, Wen‐Bo Tang, Yi‐Lin Disease progression in Parkinson‘s disease patients with subjective cognitive complaint |
title | Disease progression in Parkinson‘s disease patients with subjective cognitive complaint |
title_full | Disease progression in Parkinson‘s disease patients with subjective cognitive complaint |
title_fullStr | Disease progression in Parkinson‘s disease patients with subjective cognitive complaint |
title_full_unstemmed | Disease progression in Parkinson‘s disease patients with subjective cognitive complaint |
title_short | Disease progression in Parkinson‘s disease patients with subjective cognitive complaint |
title_sort | disease progression in parkinson‘s disease patients with subjective cognitive complaint |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528458/ https://www.ncbi.nlm.nih.gov/pubmed/34595848 http://dx.doi.org/10.1002/acn3.51461 |
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