Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the Ube3a Deletion Rat Model of Angelman Syndrome

Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder characterized by intellectual disabilities, motor and balance deficits, impaired communication, and a happy, excitable demeanor with frequent laughter. We sought to elucidate a preclinical outcome measure in male and female rats th...

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Detalles Bibliográficos
Autores principales: Berg, Elizabeth L., Jami, Shekib A., Petkova, Stela P., Berz, Annuska, Fenton, Timothy A., Lerch, Jason P., Segal, David J., Gray, John A., Ellegood, Jacob, Wöhr, Markus, Silverman, Jill L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528495/
https://www.ncbi.nlm.nih.gov/pubmed/34475199
http://dx.doi.org/10.1523/JNEUROSCI.0925-21.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528495/
https://www.ncbi.nlm.nih.gov/pubmed/34475199
http://dx.doi.org/10.1523/JNEUROSCI.0925-21.2021

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