Succinate dehydrogenase deficient renal cell carcinoma: A case report

Succinate dehydrogenase (SDH) deficient renal cell carcinoma (RCC) are uncommon renal tumors that typically present in relatively younger patients. SDH mutations are known to cause cancer, but often presents with hereditary paragangliomas, pheochromocytomas, and gastrointestinal stromal tumors. This...

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Detalles Bibliográficos
Autores principales: Kumar, Raj A., Miyagi, Hiroko, Mittal, Vimal, Crispen, Paul, Kumar, Udaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528678/
https://www.ncbi.nlm.nih.gov/pubmed/34712582
http://dx.doi.org/10.1016/j.eucr.2021.101885
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author Kumar, Raj A.
Miyagi, Hiroko
Mittal, Vimal
Crispen, Paul
Kumar, Udaya
author_facet Kumar, Raj A.
Miyagi, Hiroko
Mittal, Vimal
Crispen, Paul
Kumar, Udaya
author_sort Kumar, Raj A.
collection PubMed
description Succinate dehydrogenase (SDH) deficient renal cell carcinoma (RCC) are uncommon renal tumors that typically present in relatively younger patients. SDH mutations are known to cause cancer, but often presents with hereditary paragangliomas, pheochromocytomas, and gastrointestinal stromal tumors. This report details a case of SDH deficient RCC in a patient with no know contributing family history. Patient presented with recurrent urinary tract infections and groin pain. Computerized tomography (CT) revealed a 4 cm mass in the right kidney. Partial nephrectomy was performed, and the patient had an uneventful recovery. Immunohistochemical staining revealed the tumor was SDH negative.
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spelling pubmed-85286782021-10-27 Succinate dehydrogenase deficient renal cell carcinoma: A case report Kumar, Raj A. Miyagi, Hiroko Mittal, Vimal Crispen, Paul Kumar, Udaya Urol Case Rep Oncology Succinate dehydrogenase (SDH) deficient renal cell carcinoma (RCC) are uncommon renal tumors that typically present in relatively younger patients. SDH mutations are known to cause cancer, but often presents with hereditary paragangliomas, pheochromocytomas, and gastrointestinal stromal tumors. This report details a case of SDH deficient RCC in a patient with no know contributing family history. Patient presented with recurrent urinary tract infections and groin pain. Computerized tomography (CT) revealed a 4 cm mass in the right kidney. Partial nephrectomy was performed, and the patient had an uneventful recovery. Immunohistochemical staining revealed the tumor was SDH negative. Elsevier 2021-10-12 /pmc/articles/PMC8528678/ /pubmed/34712582 http://dx.doi.org/10.1016/j.eucr.2021.101885 Text en © 2021 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Kumar, Raj A.
Miyagi, Hiroko
Mittal, Vimal
Crispen, Paul
Kumar, Udaya
Succinate dehydrogenase deficient renal cell carcinoma: A case report
title Succinate dehydrogenase deficient renal cell carcinoma: A case report
title_full Succinate dehydrogenase deficient renal cell carcinoma: A case report
title_fullStr Succinate dehydrogenase deficient renal cell carcinoma: A case report
title_full_unstemmed Succinate dehydrogenase deficient renal cell carcinoma: A case report
title_short Succinate dehydrogenase deficient renal cell carcinoma: A case report
title_sort succinate dehydrogenase deficient renal cell carcinoma: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528678/
https://www.ncbi.nlm.nih.gov/pubmed/34712582
http://dx.doi.org/10.1016/j.eucr.2021.101885
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AT crispenpaul succinatedehydrogenasedeficientrenalcellcarcinomaacasereport
AT kumarudaya succinatedehydrogenasedeficientrenalcellcarcinomaacasereport

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