Cargando…

Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma

The incidence of keratinocyte carcinomas is increasing worldwide and currently there is no standardised strategy for the follow-up of patients with multiple tumours. The objective of this study was to assess the prevalence of premalignant lesions, i.e., actinic keratosis and Bowen’s disease, as well...

Descripción completa

Detalles Bibliográficos
Autores principales: Korhonen, Niina, Ylitalo, Leea, Luukkaala, Tiina, Itkonen, Julius, Häihälä, Henni, Jernman, Juha, Snellman, Erna, Palve, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528745/
https://www.ncbi.nlm.nih.gov/pubmed/32772261
http://dx.doi.org/10.1007/s00403-020-02114-w
_version_ 1784586313761030144
author Korhonen, Niina
Ylitalo, Leea
Luukkaala, Tiina
Itkonen, Julius
Häihälä, Henni
Jernman, Juha
Snellman, Erna
Palve, Johanna
author_facet Korhonen, Niina
Ylitalo, Leea
Luukkaala, Tiina
Itkonen, Julius
Häihälä, Henni
Jernman, Juha
Snellman, Erna
Palve, Johanna
author_sort Korhonen, Niina
collection PubMed
description The incidence of keratinocyte carcinomas is increasing worldwide and currently there is no standardised strategy for the follow-up of patients with multiple tumours. The objective of this study was to assess the prevalence of premalignant lesions, i.e., actinic keratosis and Bowen’s disease, as well as basal cell carcinoma (BCC) and cutaneous melanoma (CM) among patients with cutaneous squamous cell carcinoma (cSCC). Pathology database search was performed to identify all cSCC patients diagnosed in the Pirkanmaa region of Finland in 2006–2015. Details of the patients and tumours were obtained through medical record review. The cohort consisted of 774 patients with 1131 cSCC tumours. Overall 559 patients (72%) had premalignant lesions. A total of 316 patients (41%) had BCC and 52% of these (n = 164) had more than one BCC tumour. 50 patients (6%) had CM. Overall 180 cSCC patients (23%) had no premalignant changes, BCC or CM. The median age of these patients was 6 years less than that of the patients with premalignant lesions (p < 0.001) or BCC (p < 0.001). The invasion depth of the tumours was deeper in the patients with only cSCC (median 3 mm, interquartile range 2–6) than in those with premalignant lesions or BCC (median 2 mm, interquartile range 1–3), p < 0.001. CSCC patients have a high risk of developing multiple skin cancers and need long-term follow-up.
format Online
Article
Text
id pubmed-8528745
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-85287452021-11-04 Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma Korhonen, Niina Ylitalo, Leea Luukkaala, Tiina Itkonen, Julius Häihälä, Henni Jernman, Juha Snellman, Erna Palve, Johanna Arch Dermatol Res Concise Communication The incidence of keratinocyte carcinomas is increasing worldwide and currently there is no standardised strategy for the follow-up of patients with multiple tumours. The objective of this study was to assess the prevalence of premalignant lesions, i.e., actinic keratosis and Bowen’s disease, as well as basal cell carcinoma (BCC) and cutaneous melanoma (CM) among patients with cutaneous squamous cell carcinoma (cSCC). Pathology database search was performed to identify all cSCC patients diagnosed in the Pirkanmaa region of Finland in 2006–2015. Details of the patients and tumours were obtained through medical record review. The cohort consisted of 774 patients with 1131 cSCC tumours. Overall 559 patients (72%) had premalignant lesions. A total of 316 patients (41%) had BCC and 52% of these (n = 164) had more than one BCC tumour. 50 patients (6%) had CM. Overall 180 cSCC patients (23%) had no premalignant changes, BCC or CM. The median age of these patients was 6 years less than that of the patients with premalignant lesions (p < 0.001) or BCC (p < 0.001). The invasion depth of the tumours was deeper in the patients with only cSCC (median 3 mm, interquartile range 2–6) than in those with premalignant lesions or BCC (median 2 mm, interquartile range 1–3), p < 0.001. CSCC patients have a high risk of developing multiple skin cancers and need long-term follow-up. Springer Berlin Heidelberg 2020-08-09 2021 /pmc/articles/PMC8528745/ /pubmed/32772261 http://dx.doi.org/10.1007/s00403-020-02114-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Concise Communication
Korhonen, Niina
Ylitalo, Leea
Luukkaala, Tiina
Itkonen, Julius
Häihälä, Henni
Jernman, Juha
Snellman, Erna
Palve, Johanna
Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
title Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
title_full Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
title_fullStr Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
title_full_unstemmed Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
title_short Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
title_sort premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma
topic Concise Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528745/
https://www.ncbi.nlm.nih.gov/pubmed/32772261
http://dx.doi.org/10.1007/s00403-020-02114-w
work_keys_str_mv AT korhonenniina premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma
AT ylitaloleea premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma
AT luukkaalatiina premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma
AT itkonenjulius premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma
AT haihalahenni premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma
AT jernmanjuha premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma
AT snellmanerna premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma
AT palvejohanna premalignantlesionsbasalcellcarcinomaandmelanomainpatientswithcutaneoussquamouscellcarcinoma