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Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process
Gastric cancer (GC) ranks the third among global cancer-related mortality, especially in East Asia. Angiogenesis plays an important role in promoting tumor progression, and clinical trials have demonstrated that anti-angiogenesis therapy is effective in GC management. Natriuretic peptide receptor A...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528824/ https://www.ncbi.nlm.nih.gov/pubmed/34671022 http://dx.doi.org/10.1038/s41419-021-04266-7 |
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author | Li, Zheng Fan, Hao Cao, Jiacheng Sun, Guangli Sen Wang Lv, Jialun Xuan, Zhe Xia, Yiwen Wang, Linjun Zhang, Diancai Xu, Hao Xu, Zekuan |
author_facet | Li, Zheng Fan, Hao Cao, Jiacheng Sun, Guangli Sen Wang Lv, Jialun Xuan, Zhe Xia, Yiwen Wang, Linjun Zhang, Diancai Xu, Hao Xu, Zekuan |
author_sort | Li, Zheng |
collection | PubMed |
description | Gastric cancer (GC) ranks the third among global cancer-related mortality, especially in East Asia. Angiogenesis plays an important role in promoting tumor progression, and clinical trials have demonstrated that anti-angiogenesis therapy is effective in GC management. Natriuretic peptide receptor A (NPRA) functions significantly in promoting GC development and progression. Whether NPRA can promote angiogenesis of GC remains unclear. Tumor samples collection and immunohistochemical experiment showed that the expression of NPRA was positively correlated with the expression of CD31 and vessel density. In vivo and in vitro analysis showed that NPRA could promote GC-associated angiogenesis and tumor metastasis. Results of Co-IP/MS showed that NPRA could prevent HIF-1α from being degraded by binding to HIF-1α. Protection of HIF-1α improved VEGF levels and thus promoted angiogenesis. In summary, NPRA protected HIF-1α from proteolysis by binding to HIF-1α, increased the expression of HIF-1α, and promoted GC angiogenesis. This study has discovered a new mechanism for NPRA to promote gastric cancer development and a new regulatory mechanism for HIF-1α. |
format | Online Article Text |
id | pubmed-8528824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85288242021-10-22 Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process Li, Zheng Fan, Hao Cao, Jiacheng Sun, Guangli Sen Wang Lv, Jialun Xuan, Zhe Xia, Yiwen Wang, Linjun Zhang, Diancai Xu, Hao Xu, Zekuan Cell Death Dis Article Gastric cancer (GC) ranks the third among global cancer-related mortality, especially in East Asia. Angiogenesis plays an important role in promoting tumor progression, and clinical trials have demonstrated that anti-angiogenesis therapy is effective in GC management. Natriuretic peptide receptor A (NPRA) functions significantly in promoting GC development and progression. Whether NPRA can promote angiogenesis of GC remains unclear. Tumor samples collection and immunohistochemical experiment showed that the expression of NPRA was positively correlated with the expression of CD31 and vessel density. In vivo and in vitro analysis showed that NPRA could promote GC-associated angiogenesis and tumor metastasis. Results of Co-IP/MS showed that NPRA could prevent HIF-1α from being degraded by binding to HIF-1α. Protection of HIF-1α improved VEGF levels and thus promoted angiogenesis. In summary, NPRA protected HIF-1α from proteolysis by binding to HIF-1α, increased the expression of HIF-1α, and promoted GC angiogenesis. This study has discovered a new mechanism for NPRA to promote gastric cancer development and a new regulatory mechanism for HIF-1α. Nature Publishing Group UK 2021-10-20 /pmc/articles/PMC8528824/ /pubmed/34671022 http://dx.doi.org/10.1038/s41419-021-04266-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Zheng Fan, Hao Cao, Jiacheng Sun, Guangli Sen Wang Lv, Jialun Xuan, Zhe Xia, Yiwen Wang, Linjun Zhang, Diancai Xu, Hao Xu, Zekuan Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process |
title | Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process |
title_full | Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process |
title_fullStr | Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process |
title_full_unstemmed | Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process |
title_short | Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process |
title_sort | natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528824/ https://www.ncbi.nlm.nih.gov/pubmed/34671022 http://dx.doi.org/10.1038/s41419-021-04266-7 |
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