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Lateralization of CA1 assemblies in the absence of CA3 input
In the hippocampal circuit CA3 input plays a critical role in the organization of CA1 population activity, both during learning and sleep. While integrated spatial representations have been observed across the two hemispheres of CA1, these regions lack direct connectivity and thus the circuitry resp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528853/ https://www.ncbi.nlm.nih.gov/pubmed/34671042 http://dx.doi.org/10.1038/s41467-021-26389-3 |
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author | Guan, Hefei Middleton, Steven J. Inoue, Takafumi McHugh, Thomas J. |
author_facet | Guan, Hefei Middleton, Steven J. Inoue, Takafumi McHugh, Thomas J. |
author_sort | Guan, Hefei |
collection | PubMed |
description | In the hippocampal circuit CA3 input plays a critical role in the organization of CA1 population activity, both during learning and sleep. While integrated spatial representations have been observed across the two hemispheres of CA1, these regions lack direct connectivity and thus the circuitry responsible remains largely unexplored. Here we investigate the role of CA3 in organizing bilateral CA1 activity by blocking synaptic transmission at CA3 terminals through the inducible transgenic expression of tetanus toxin. Although the properties of single place cells in CA1 were comparable bilaterally, we find a decrease of ripple synchronization between left and right CA1 after silencing CA3. Further, during both exploration and rest, CA1 neuronal ensemble activity is less coordinated across hemispheres. This included degradation of the replay of previously explored spatial paths in CA1 during rest, consistent with the idea that CA3 bilateral projections integrate activity between left and right hemispheres and orchestrate bilateral hippocampal coding. |
format | Online Article Text |
id | pubmed-8528853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85288532021-10-22 Lateralization of CA1 assemblies in the absence of CA3 input Guan, Hefei Middleton, Steven J. Inoue, Takafumi McHugh, Thomas J. Nat Commun Article In the hippocampal circuit CA3 input plays a critical role in the organization of CA1 population activity, both during learning and sleep. While integrated spatial representations have been observed across the two hemispheres of CA1, these regions lack direct connectivity and thus the circuitry responsible remains largely unexplored. Here we investigate the role of CA3 in organizing bilateral CA1 activity by blocking synaptic transmission at CA3 terminals through the inducible transgenic expression of tetanus toxin. Although the properties of single place cells in CA1 were comparable bilaterally, we find a decrease of ripple synchronization between left and right CA1 after silencing CA3. Further, during both exploration and rest, CA1 neuronal ensemble activity is less coordinated across hemispheres. This included degradation of the replay of previously explored spatial paths in CA1 during rest, consistent with the idea that CA3 bilateral projections integrate activity between left and right hemispheres and orchestrate bilateral hippocampal coding. Nature Publishing Group UK 2021-10-20 /pmc/articles/PMC8528853/ /pubmed/34671042 http://dx.doi.org/10.1038/s41467-021-26389-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Guan, Hefei Middleton, Steven J. Inoue, Takafumi McHugh, Thomas J. Lateralization of CA1 assemblies in the absence of CA3 input |
title | Lateralization of CA1 assemblies in the absence of CA3 input |
title_full | Lateralization of CA1 assemblies in the absence of CA3 input |
title_fullStr | Lateralization of CA1 assemblies in the absence of CA3 input |
title_full_unstemmed | Lateralization of CA1 assemblies in the absence of CA3 input |
title_short | Lateralization of CA1 assemblies in the absence of CA3 input |
title_sort | lateralization of ca1 assemblies in the absence of ca3 input |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528853/ https://www.ncbi.nlm.nih.gov/pubmed/34671042 http://dx.doi.org/10.1038/s41467-021-26389-3 |
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