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Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derangement using two mouse models of PKD1 mutation, PKD1(RC/null) and PKD1(RC/RC). Mouse kidneys...

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Detalles Bibliográficos
Autores principales:	Daneshgar, Nastaran, Baguley, Andrew W., Liang, Peir-In, Wu, Fei, Chu, Yi, Kinter, Michael T., Benavides, Gloria A., Johnson, Michelle S., Darley-Usmar, Victor, Zhang, Jianhua, Chan, Kung-Sik, Dai, Dao-Fu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528863/ https://www.ncbi.nlm.nih.gov/pubmed/34671066 http://dx.doi.org/10.1038/s42003-021-02730-w

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