The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia

Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein...

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Autores principales: Goldsmith, David R., Massa, Nicholas, Miller, Brian J., Miller, Andrew H., Duncan, Erica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528914/
https://www.ncbi.nlm.nih.gov/pubmed/34671033
http://dx.doi.org/10.1038/s41537-021-00179-8
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author Goldsmith, David R.
Massa, Nicholas
Miller, Brian J.
Miller, Andrew H.
Duncan, Erica
author_facet Goldsmith, David R.
Massa, Nicholas
Miller, Brian J.
Miller, Andrew H.
Duncan, Erica
author_sort Goldsmith, David R.
collection PubMed
description Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relationship and thereby reveal novel treatment targets for negative symptoms.
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spelling pubmed-85289142021-10-22 The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia Goldsmith, David R. Massa, Nicholas Miller, Brian J. Miller, Andrew H. Duncan, Erica NPJ Schizophr Brief Communication Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relationship and thereby reveal novel treatment targets for negative symptoms. Nature Publishing Group UK 2021-10-20 /pmc/articles/PMC8528914/ /pubmed/34671033 http://dx.doi.org/10.1038/s41537-021-00179-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Goldsmith, David R.
Massa, Nicholas
Miller, Brian J.
Miller, Andrew H.
Duncan, Erica
The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
title The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
title_full The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
title_fullStr The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
title_full_unstemmed The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
title_short The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
title_sort interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528914/
https://www.ncbi.nlm.nih.gov/pubmed/34671033
http://dx.doi.org/10.1038/s41537-021-00179-8
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