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A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis
BACKGROUND: Polymyositis and myocarditis associated with thymoma are exceptionally rare conditions and usually accompanied by myasthenia gravis (MG) and have been recognized as critical conditions. Thymoma-associated multiorgan autoimmunity was reported recently with skin, liver, and intestinal mani...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528923/ https://www.ncbi.nlm.nih.gov/pubmed/34669063 http://dx.doi.org/10.1186/s40792-021-01309-1 |
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author | Furuta, Chihiro Yano, Motoki Numanami, Hiroki Yamaji, Masayuki Taguchi, Rumiko Haniuda, Masayuki |
author_facet | Furuta, Chihiro Yano, Motoki Numanami, Hiroki Yamaji, Masayuki Taguchi, Rumiko Haniuda, Masayuki |
author_sort | Furuta, Chihiro |
collection | PubMed |
description | BACKGROUND: Polymyositis and myocarditis associated with thymoma are exceptionally rare conditions and usually accompanied by myasthenia gravis (MG) and have been recognized as critical conditions. Thymoma-associated multiorgan autoimmunity was reported recently with skin, liver, and intestinal manifestations similar to those seen in graft-versus-host disease. CASE PRESENTATION: A 77-year-old female presented to our department with exacerbation of ptosis and local recurrence of thymoma. Chest computed tomography revealed local recurrence of thymoma. Following 6 month observation, erythema on the extremities and body trunk suddenly appeared. Afterwards, the patient developed progressive muscle weakness and fatigue. We diagnosed as myocarditis and polymyositis. She was transferred to the intensive-care unit and received artificial ventilation. Steroid pulse therapy was induced immediately. The blood test findings were markedly improved, but the symptoms of MG and weakness of the muscles persisted. Various treatment including eculizumab was induced, and the symptoms of MG and weakness of the muscles were improved. On the 136th day of hospitalization, she was discharged. CONCLUSION: We were able to cure this patient, as we were able to start treatment immediately after the appearance of severe symptoms. An early diagnosis and treatment are important for curing such patients. |
format | Online Article Text |
id | pubmed-8528923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-85289232021-11-04 A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis Furuta, Chihiro Yano, Motoki Numanami, Hiroki Yamaji, Masayuki Taguchi, Rumiko Haniuda, Masayuki Surg Case Rep Case Report BACKGROUND: Polymyositis and myocarditis associated with thymoma are exceptionally rare conditions and usually accompanied by myasthenia gravis (MG) and have been recognized as critical conditions. Thymoma-associated multiorgan autoimmunity was reported recently with skin, liver, and intestinal manifestations similar to those seen in graft-versus-host disease. CASE PRESENTATION: A 77-year-old female presented to our department with exacerbation of ptosis and local recurrence of thymoma. Chest computed tomography revealed local recurrence of thymoma. Following 6 month observation, erythema on the extremities and body trunk suddenly appeared. Afterwards, the patient developed progressive muscle weakness and fatigue. We diagnosed as myocarditis and polymyositis. She was transferred to the intensive-care unit and received artificial ventilation. Steroid pulse therapy was induced immediately. The blood test findings were markedly improved, but the symptoms of MG and weakness of the muscles persisted. Various treatment including eculizumab was induced, and the symptoms of MG and weakness of the muscles were improved. On the 136th day of hospitalization, she was discharged. CONCLUSION: We were able to cure this patient, as we were able to start treatment immediately after the appearance of severe symptoms. An early diagnosis and treatment are important for curing such patients. Springer Berlin Heidelberg 2021-10-20 /pmc/articles/PMC8528923/ /pubmed/34669063 http://dx.doi.org/10.1186/s40792-021-01309-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Case Report Furuta, Chihiro Yano, Motoki Numanami, Hiroki Yamaji, Masayuki Taguchi, Rumiko Haniuda, Masayuki A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis |
title | A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis |
title_full | A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis |
title_fullStr | A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis |
title_full_unstemmed | A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis |
title_short | A case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis |
title_sort | case of thymoma-associated multiorgan autoimmunity including polymyositis and myocarditis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528923/ https://www.ncbi.nlm.nih.gov/pubmed/34669063 http://dx.doi.org/10.1186/s40792-021-01309-1 |
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