Cargando…
Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening
Monoclonal antibodies that target SARS-CoV-2 with high affinity are valuable for a wide range of biomedical applications involving novel coronavirus disease (COVID-19) diagnosis, treatment, and prophylactic intervention. Strategies for the rapid and reliable isolation of these antibodies, especially...
Autores principales: | Schardt, John S., Pornnoppadol, Ghasidit, Desai, Alec A., Park, Kyung Soo, Zupancic, Jennifer M., Makowski, Emily K., Smith, Matthew D., Chen, Hongwei, Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Moon, James J., Tessier, Peter M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528929/ https://www.ncbi.nlm.nih.gov/pubmed/34671080 http://dx.doi.org/10.1038/s41598-021-99401-x |
Ejemplares similares
-
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis
por: Zupancic, Jennifer M., et al.
Publicado: (2021) -
A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain
por: Pornnoppadol, Ghasidit, et al.
Publicado: (2021) -
38227 Specific and highly potent human monoclonal antibodies against SARS-CoV-2
por: de Mattos Barbosa, Mayara Garcia, et al.
Publicado: (2021) -
Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis
por: Zupancic, Jennifer M., et al.
Publicado: (2022) -
Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space
por: Makowski, Emily K., et al.
Publicado: (2022)