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Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

Influenza virus alters glycosylation patterns on its surface exposed glycoproteins to evade host adaptive immune responses. The viral hemagglutinin (HA), in particular the H3 subtype, has increased its overall surface glycosylation since its introduction in 1968. We previously showed that modulating...

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Detalles Bibliográficos
Autores principales:	Thornlow, Dana N., Macintyre, Andrew N., Oguin, Thomas H., Karlsson, Amelia B., Stover, Erica L., Lynch, Heather E., Sempowski, Gregory D., Schmidt, Aaron G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528956/ https://www.ncbi.nlm.nih.gov/pubmed/34691043 http://dx.doi.org/10.3389/fimmu.2021.737973

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