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The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice

Accumulating evidence has demonstrated that the imbalance of lipid metabolism and antioxidant capacity leads to damage to liver. The present study aimed to investigate the effects of ellagic acid (EA), a phenolic compound, on hepatic lipid metabolism and antioxidant activity in mice. In our study, 2...

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Autores principales: Xu, Qiuying, Li, Shuwei, Tang, Wenjie, Yan, Jiayou, Wei, Xiaolan, Zhou, Mengjia, Diao, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529006/
https://www.ncbi.nlm.nih.gov/pubmed/34690819
http://dx.doi.org/10.3389/fphys.2021.751501
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author Xu, Qiuying
Li, Shuwei
Tang, Wenjie
Yan, Jiayou
Wei, Xiaolan
Zhou, Mengjia
Diao, Hui
author_facet Xu, Qiuying
Li, Shuwei
Tang, Wenjie
Yan, Jiayou
Wei, Xiaolan
Zhou, Mengjia
Diao, Hui
author_sort Xu, Qiuying
collection PubMed
description Accumulating evidence has demonstrated that the imbalance of lipid metabolism and antioxidant capacity leads to damage to liver. The present study aimed to investigate the effects of ellagic acid (EA), a phenolic compound, on hepatic lipid metabolism and antioxidant activity in mice. In our study, 24 C57BL/6J mice were divided into three groups: (1) control (CON); (2) basal diet+0.1% EA (EA1); and (3) basal diet+0.3% EA (EA2). After the 14-day experiment, the liver was sampled for analysis. The results showed that 0.3% EA administration increased the liver weight. Total cholesterol and low-density lipoprotein cholesterol activities decreased and high-density lipoprotein cholesterol activity increased by EA supplementation. Meanwhile, dietary supplementation with EA dose-dependently decreased the acetyl-CoA carboxylase protein abundance and increased the phospho-hormone-sensitive lipase, carnitine palmitoyltransferase 1B, and peroxisome proliferator-activated receptor alpha protein abundances. Moreover, EA supplementation reduced the malonaldehyde concentration and increased the superoxide dismutase and catalase concentrations. The protein abundances of phospho-nuclear factor-E2-related factor 2, heme oxygenase-1, and NAD(P)H: quinone oxidoreductase 1 increased by EA supplementation in a dose-dependent manner. Taken together, EA supplementation promoted the lipid metabolism and antioxidant capacity to maintain the liver health in mice.
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spelling pubmed-85290062021-10-22 The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice Xu, Qiuying Li, Shuwei Tang, Wenjie Yan, Jiayou Wei, Xiaolan Zhou, Mengjia Diao, Hui Front Physiol Physiology Accumulating evidence has demonstrated that the imbalance of lipid metabolism and antioxidant capacity leads to damage to liver. The present study aimed to investigate the effects of ellagic acid (EA), a phenolic compound, on hepatic lipid metabolism and antioxidant activity in mice. In our study, 24 C57BL/6J mice were divided into three groups: (1) control (CON); (2) basal diet+0.1% EA (EA1); and (3) basal diet+0.3% EA (EA2). After the 14-day experiment, the liver was sampled for analysis. The results showed that 0.3% EA administration increased the liver weight. Total cholesterol and low-density lipoprotein cholesterol activities decreased and high-density lipoprotein cholesterol activity increased by EA supplementation. Meanwhile, dietary supplementation with EA dose-dependently decreased the acetyl-CoA carboxylase protein abundance and increased the phospho-hormone-sensitive lipase, carnitine palmitoyltransferase 1B, and peroxisome proliferator-activated receptor alpha protein abundances. Moreover, EA supplementation reduced the malonaldehyde concentration and increased the superoxide dismutase and catalase concentrations. The protein abundances of phospho-nuclear factor-E2-related factor 2, heme oxygenase-1, and NAD(P)H: quinone oxidoreductase 1 increased by EA supplementation in a dose-dependent manner. Taken together, EA supplementation promoted the lipid metabolism and antioxidant capacity to maintain the liver health in mice. Frontiers Media S.A. 2021-10-07 /pmc/articles/PMC8529006/ /pubmed/34690819 http://dx.doi.org/10.3389/fphys.2021.751501 Text en Copyright © 2021 Xu, Li, Tang, Yan, Wei, Zhou and Diao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Xu, Qiuying
Li, Shuwei
Tang, Wenjie
Yan, Jiayou
Wei, Xiaolan
Zhou, Mengjia
Diao, Hui
The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice
title The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice
title_full The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice
title_fullStr The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice
title_full_unstemmed The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice
title_short The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice
title_sort effect of ellagic acid on hepatic lipid metabolism and antioxidant activity in mice
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529006/
https://www.ncbi.nlm.nih.gov/pubmed/34690819
http://dx.doi.org/10.3389/fphys.2021.751501
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