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The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria

Cerebral malaria (CM) is a severe neurological complication of malaria caused by the Plasmodium falciparum parasite. It is one of the leading causes of death in children under 5 years of age in Sub-Saharan Africa. CM is associated with blood-brain barrier disruption and long-term neurological sequel...

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Detalles Bibliográficos
Autores principales: Andoh, Nana Efua, Gyan, Ben Adu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529055/
https://www.ncbi.nlm.nih.gov/pubmed/34692564
http://dx.doi.org/10.3389/fcimb.2021.741370
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author Andoh, Nana Efua
Gyan, Ben Adu
author_facet Andoh, Nana Efua
Gyan, Ben Adu
author_sort Andoh, Nana Efua
collection PubMed
description Cerebral malaria (CM) is a severe neurological complication of malaria caused by the Plasmodium falciparum parasite. It is one of the leading causes of death in children under 5 years of age in Sub-Saharan Africa. CM is associated with blood-brain barrier disruption and long-term neurological sequelae in survivors of CM. Despite the vast amount of research on cerebral malaria, the cause of neurological sequelae observed in CM patients is poorly understood. In this article, the potential roles of glial cells, astrocytes, and microglia, in cerebral malaria pathogenesis are reviewed. The possible mechanisms by which glial cells contribute to neurological damage in CM patients are also examined.
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spelling pubmed-85290552021-10-22 The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria Andoh, Nana Efua Gyan, Ben Adu Front Cell Infect Microbiol Cellular and Infection Microbiology Cerebral malaria (CM) is a severe neurological complication of malaria caused by the Plasmodium falciparum parasite. It is one of the leading causes of death in children under 5 years of age in Sub-Saharan Africa. CM is associated with blood-brain barrier disruption and long-term neurological sequelae in survivors of CM. Despite the vast amount of research on cerebral malaria, the cause of neurological sequelae observed in CM patients is poorly understood. In this article, the potential roles of glial cells, astrocytes, and microglia, in cerebral malaria pathogenesis are reviewed. The possible mechanisms by which glial cells contribute to neurological damage in CM patients are also examined. Frontiers Media S.A. 2021-10-07 /pmc/articles/PMC8529055/ /pubmed/34692564 http://dx.doi.org/10.3389/fcimb.2021.741370 Text en Copyright © 2021 Andoh and Gyan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Andoh, Nana Efua
Gyan, Ben Adu
The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria
title The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria
title_full The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria
title_fullStr The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria
title_full_unstemmed The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria
title_short The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria
title_sort potential roles of glial cells in the neuropathogenesis of cerebral malaria
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529055/
https://www.ncbi.nlm.nih.gov/pubmed/34692564
http://dx.doi.org/10.3389/fcimb.2021.741370
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