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The Role of Microbiota in Infant Health: From Early Life to Adulthood

From early life to adulthood, the microbiota play a crucial role in the health of the infant. The microbiota in early life are not only a key regulator of infant health but also associated with long-term health. Pregnancy to early life is the golden time for the establishment of the infant microbiot...

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Autores principales: Yao, Yao, Cai, Xiaoyu, Ye, Yiqing, Wang, Fengmei, Chen, Fengying, Zheng, Caihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529064/
https://www.ncbi.nlm.nih.gov/pubmed/34691021
http://dx.doi.org/10.3389/fimmu.2021.708472
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author Yao, Yao
Cai, Xiaoyu
Ye, Yiqing
Wang, Fengmei
Chen, Fengying
Zheng, Caihong
author_facet Yao, Yao
Cai, Xiaoyu
Ye, Yiqing
Wang, Fengmei
Chen, Fengying
Zheng, Caihong
author_sort Yao, Yao
collection PubMed
description From early life to adulthood, the microbiota play a crucial role in the health of the infant. The microbiota in early life are not only a key regulator of infant health but also associated with long-term health. Pregnancy to early life is the golden time for the establishment of the infant microbiota, which is affected by both environmental and genetic factors. Recently, there is an explosion of the studies on the role of microbiota in human diseases, but the application to disease or health is relatively limited because many aspects of human microbiota remain controversial, especially about the infant microbiota. Therefore, a critical and conclusive review is necessary to understand fully the relationship between the microbiota and the health of infant. In this article, we introduce in detail the role of microbiota in the infant from pregnancy to early life to long-term health. The main contents of this article include the relationship between the maternal microbiota and adverse pregnancy outcomes, the establishment of the neonatal microbiota during perinatal period and early life, the composition of the infant gut microbiota, the prediction of the microbiota for long-term health, and the future study directions of microbiota.
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spelling pubmed-85290642021-10-22 The Role of Microbiota in Infant Health: From Early Life to Adulthood Yao, Yao Cai, Xiaoyu Ye, Yiqing Wang, Fengmei Chen, Fengying Zheng, Caihong Front Immunol Immunology From early life to adulthood, the microbiota play a crucial role in the health of the infant. The microbiota in early life are not only a key regulator of infant health but also associated with long-term health. Pregnancy to early life is the golden time for the establishment of the infant microbiota, which is affected by both environmental and genetic factors. Recently, there is an explosion of the studies on the role of microbiota in human diseases, but the application to disease or health is relatively limited because many aspects of human microbiota remain controversial, especially about the infant microbiota. Therefore, a critical and conclusive review is necessary to understand fully the relationship between the microbiota and the health of infant. In this article, we introduce in detail the role of microbiota in the infant from pregnancy to early life to long-term health. The main contents of this article include the relationship between the maternal microbiota and adverse pregnancy outcomes, the establishment of the neonatal microbiota during perinatal period and early life, the composition of the infant gut microbiota, the prediction of the microbiota for long-term health, and the future study directions of microbiota. Frontiers Media S.A. 2021-10-07 /pmc/articles/PMC8529064/ /pubmed/34691021 http://dx.doi.org/10.3389/fimmu.2021.708472 Text en Copyright © 2021 Yao, Cai, Ye, Wang, Chen and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yao, Yao
Cai, Xiaoyu
Ye, Yiqing
Wang, Fengmei
Chen, Fengying
Zheng, Caihong
The Role of Microbiota in Infant Health: From Early Life to Adulthood
title The Role of Microbiota in Infant Health: From Early Life to Adulthood
title_full The Role of Microbiota in Infant Health: From Early Life to Adulthood
title_fullStr The Role of Microbiota in Infant Health: From Early Life to Adulthood
title_full_unstemmed The Role of Microbiota in Infant Health: From Early Life to Adulthood
title_short The Role of Microbiota in Infant Health: From Early Life to Adulthood
title_sort role of microbiota in infant health: from early life to adulthood
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529064/
https://www.ncbi.nlm.nih.gov/pubmed/34691021
http://dx.doi.org/10.3389/fimmu.2021.708472
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