MCM3AP-AS1: An Indispensable Cancer-Related LncRNA

Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, t...

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Autores principales: Yu, Xiao, Zheng, Qingyuan, Zhang, Qiyao, Zhang, Shuijun, He, Yuting, Guo, Wenzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529123/
https://www.ncbi.nlm.nih.gov/pubmed/34692706
http://dx.doi.org/10.3389/fcell.2021.752718
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author Yu, Xiao
Zheng, Qingyuan
Zhang, Qiyao
Zhang, Shuijun
He, Yuting
Guo, Wenzhi
author_facet Yu, Xiao
Zheng, Qingyuan
Zhang, Qiyao
Zhang, Shuijun
He, Yuting
Guo, Wenzhi
author_sort Yu, Xiao
collection PubMed
description Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, tumor-node-metastasis (TNM) stage, and pathological grade. Additionally, it considerably promotes or suppresses tumor progression by controlling the biological functions of cells. MCM3AP-AS1 is a promising biomarker for cancer diagnosis, prognosis evaluation, and treatment. In this review, we briefly summarized the published studies on the expression, biological function, and regulatory mechanisms of MCM3AP-AS1. We also discussed the clinical applications of MCM3AP-AS1 as a biomarker.
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spelling pubmed-85291232021-10-22 MCM3AP-AS1: An Indispensable Cancer-Related LncRNA Yu, Xiao Zheng, Qingyuan Zhang, Qiyao Zhang, Shuijun He, Yuting Guo, Wenzhi Front Cell Dev Biol Cell and Developmental Biology Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, tumor-node-metastasis (TNM) stage, and pathological grade. Additionally, it considerably promotes or suppresses tumor progression by controlling the biological functions of cells. MCM3AP-AS1 is a promising biomarker for cancer diagnosis, prognosis evaluation, and treatment. In this review, we briefly summarized the published studies on the expression, biological function, and regulatory mechanisms of MCM3AP-AS1. We also discussed the clinical applications of MCM3AP-AS1 as a biomarker. Frontiers Media S.A. 2021-10-07 /pmc/articles/PMC8529123/ /pubmed/34692706 http://dx.doi.org/10.3389/fcell.2021.752718 Text en Copyright © 2021 Yu, Zheng, Zhang, Zhang, He and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yu, Xiao
Zheng, Qingyuan
Zhang, Qiyao
Zhang, Shuijun
He, Yuting
Guo, Wenzhi
MCM3AP-AS1: An Indispensable Cancer-Related LncRNA
title MCM3AP-AS1: An Indispensable Cancer-Related LncRNA
title_full MCM3AP-AS1: An Indispensable Cancer-Related LncRNA
title_fullStr MCM3AP-AS1: An Indispensable Cancer-Related LncRNA
title_full_unstemmed MCM3AP-AS1: An Indispensable Cancer-Related LncRNA
title_short MCM3AP-AS1: An Indispensable Cancer-Related LncRNA
title_sort mcm3ap-as1: an indispensable cancer-related lncrna
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529123/
https://www.ncbi.nlm.nih.gov/pubmed/34692706
http://dx.doi.org/10.3389/fcell.2021.752718
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