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HPV infections in retinoblastoma: a systematic review
BACKGROUND: Retinoblastoma is the most common primary intraocular malignancy in children less than 4 years. Retinoblastoma (RB) contains about 3%–5% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529131/ https://www.ncbi.nlm.nih.gov/pubmed/34462972 http://dx.doi.org/10.1002/jcla.23981 |
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author | Soltani, Saber Tabibzadeh, Alireza Yousefi, Parastoo Zandi, Milad Zakeri, Armin Akhavan Rezayat, Sara Ramezani, Akam Esghaei, Maryam Farahani, Abbas |
author_facet | Soltani, Saber Tabibzadeh, Alireza Yousefi, Parastoo Zandi, Milad Zakeri, Armin Akhavan Rezayat, Sara Ramezani, Akam Esghaei, Maryam Farahani, Abbas |
author_sort | Soltani, Saber |
collection | PubMed |
description | BACKGROUND: Retinoblastoma is the most common primary intraocular malignancy in children less than 4 years. Retinoblastoma (RB) contains about 3%–5% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus (HPV). The objective of the current systematic review study was to present conducted studies in the field of HPV infection and its possible role in retinoblastoma. METHODS: For this systematic review, all relevant original research studies were assessed by searching in electronic databases include PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant keywords. The study was designed based on the PRISMA criteria. All publications with English literature and original researches are considered for screening. RESULTS: Conducted search results lead to 4070 studies. The title and abstract screening lead to 11 studies. Data extraction was performed on 8 included studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 and 18 were the most detected types. The most used method for the detection of the viruses was PCR, and the most assessed sample was formalin‐fixed, paraffin‐embedded tissue blocks. CONCLUSION: The association between HPV and retinoblastoma is still inconsistent. The prevalence of the HPV in RB was ranged from 0 to 69%, which indicates a wide range and highlights the importance of further investigation for more accurate statistical of HPV prevalence in RB. Thus, further worldwide studies of larger sample sizes of cohorts should be investigated to clarify this uncertainty. |
format | Online Article Text |
id | pubmed-8529131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85291312021-10-27 HPV infections in retinoblastoma: a systematic review Soltani, Saber Tabibzadeh, Alireza Yousefi, Parastoo Zandi, Milad Zakeri, Armin Akhavan Rezayat, Sara Ramezani, Akam Esghaei, Maryam Farahani, Abbas J Clin Lab Anal Review Article BACKGROUND: Retinoblastoma is the most common primary intraocular malignancy in children less than 4 years. Retinoblastoma (RB) contains about 3%–5% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus (HPV). The objective of the current systematic review study was to present conducted studies in the field of HPV infection and its possible role in retinoblastoma. METHODS: For this systematic review, all relevant original research studies were assessed by searching in electronic databases include PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant keywords. The study was designed based on the PRISMA criteria. All publications with English literature and original researches are considered for screening. RESULTS: Conducted search results lead to 4070 studies. The title and abstract screening lead to 11 studies. Data extraction was performed on 8 included studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 and 18 were the most detected types. The most used method for the detection of the viruses was PCR, and the most assessed sample was formalin‐fixed, paraffin‐embedded tissue blocks. CONCLUSION: The association between HPV and retinoblastoma is still inconsistent. The prevalence of the HPV in RB was ranged from 0 to 69%, which indicates a wide range and highlights the importance of further investigation for more accurate statistical of HPV prevalence in RB. Thus, further worldwide studies of larger sample sizes of cohorts should be investigated to clarify this uncertainty. John Wiley and Sons Inc. 2021-08-30 /pmc/articles/PMC8529131/ /pubmed/34462972 http://dx.doi.org/10.1002/jcla.23981 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Article Soltani, Saber Tabibzadeh, Alireza Yousefi, Parastoo Zandi, Milad Zakeri, Armin Akhavan Rezayat, Sara Ramezani, Akam Esghaei, Maryam Farahani, Abbas HPV infections in retinoblastoma: a systematic review |
title | HPV infections in retinoblastoma: a systematic review |
title_full | HPV infections in retinoblastoma: a systematic review |
title_fullStr | HPV infections in retinoblastoma: a systematic review |
title_full_unstemmed | HPV infections in retinoblastoma: a systematic review |
title_short | HPV infections in retinoblastoma: a systematic review |
title_sort | hpv infections in retinoblastoma: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529131/ https://www.ncbi.nlm.nih.gov/pubmed/34462972 http://dx.doi.org/10.1002/jcla.23981 |
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