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Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair
Preserving genome integrity through repair of DNA damage is critical for human health and defects in these pathways lead to a variety of pathologies, most notably cancer. The social amoeba Dictyostelium discoideum is remarkably resistant to DNA damaging agents and genome analysis reveals it contains...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529158/ https://www.ncbi.nlm.nih.gov/pubmed/34692705 http://dx.doi.org/10.3389/fcell.2021.752175 |
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author | Pears, Catherine J. Brustel, Julien Lakin, Nicholas D. |
author_facet | Pears, Catherine J. Brustel, Julien Lakin, Nicholas D. |
author_sort | Pears, Catherine J. |
collection | PubMed |
description | Preserving genome integrity through repair of DNA damage is critical for human health and defects in these pathways lead to a variety of pathologies, most notably cancer. The social amoeba Dictyostelium discoideum is remarkably resistant to DNA damaging agents and genome analysis reveals it contains orthologs of several DNA repair pathway components otherwise limited to vertebrates. These include the Fanconi Anemia DNA inter-strand crosslink and DNA strand break repair pathways. Loss of function of these not only results in malignancy, but also neurodegeneration, immune-deficiencies and congenital abnormalities. Additionally, D. discoideum displays remarkable conservations of DNA repair factors that are targets in cancer and other therapies, including poly(ADP-ribose) polymerases that are targeted to treat breast and ovarian cancers. This, taken together with the genetic tractability of D. discoideum, make it an attractive model to assess the mechanistic basis of DNA repair to provide novel insights into how these pathways can be targeted to treat a variety of pathologies. Here we describe progress in understanding the mechanisms of DNA repair in D. discoideum, and how these impact on genome stability with implications for understanding development of malignancy. |
format | Online Article Text |
id | pubmed-8529158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85291582021-10-22 Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair Pears, Catherine J. Brustel, Julien Lakin, Nicholas D. Front Cell Dev Biol Cell and Developmental Biology Preserving genome integrity through repair of DNA damage is critical for human health and defects in these pathways lead to a variety of pathologies, most notably cancer. The social amoeba Dictyostelium discoideum is remarkably resistant to DNA damaging agents and genome analysis reveals it contains orthologs of several DNA repair pathway components otherwise limited to vertebrates. These include the Fanconi Anemia DNA inter-strand crosslink and DNA strand break repair pathways. Loss of function of these not only results in malignancy, but also neurodegeneration, immune-deficiencies and congenital abnormalities. Additionally, D. discoideum displays remarkable conservations of DNA repair factors that are targets in cancer and other therapies, including poly(ADP-ribose) polymerases that are targeted to treat breast and ovarian cancers. This, taken together with the genetic tractability of D. discoideum, make it an attractive model to assess the mechanistic basis of DNA repair to provide novel insights into how these pathways can be targeted to treat a variety of pathologies. Here we describe progress in understanding the mechanisms of DNA repair in D. discoideum, and how these impact on genome stability with implications for understanding development of malignancy. Frontiers Media S.A. 2021-10-07 /pmc/articles/PMC8529158/ /pubmed/34692705 http://dx.doi.org/10.3389/fcell.2021.752175 Text en Copyright © 2021 Pears, Brustel and Lakin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Pears, Catherine J. Brustel, Julien Lakin, Nicholas D. Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair |
title | Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair |
title_full | Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair |
title_fullStr | Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair |
title_full_unstemmed | Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair |
title_short | Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair |
title_sort | dictyostelium discoideum as a model to assess genome stability through dna repair |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529158/ https://www.ncbi.nlm.nih.gov/pubmed/34692705 http://dx.doi.org/10.3389/fcell.2021.752175 |
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