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Structural and Functional Characteristics of Color Vision Changes in Choroideremia

Color vision is considered a marker of cone function and its assessment in patients with retinal pathology is complementary to the assessments of spatial vision [best-corrected visual acuity (BCVA)] and contrast detection (perimetry). Rod-cone and chorioretinal dystrophies—such as choroideremia—typi...

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Autores principales: Jolly, Jasleen K., Simunovic, Matthew P., Dubis, Adam M., Josan, Amandeep S., Robson, Anthony G., Bellini, Marco P., Bloch, Edward, Georgiadis, Odysseas, da Cruz, Lyndon, Bridge, Holly, MacLaren, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529211/
https://www.ncbi.nlm.nih.gov/pubmed/34690675
http://dx.doi.org/10.3389/fnins.2021.729807
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author Jolly, Jasleen K.
Simunovic, Matthew P.
Dubis, Adam M.
Josan, Amandeep S.
Robson, Anthony G.
Bellini, Marco P.
Bloch, Edward
Georgiadis, Odysseas
da Cruz, Lyndon
Bridge, Holly
MacLaren, Robert E.
author_facet Jolly, Jasleen K.
Simunovic, Matthew P.
Dubis, Adam M.
Josan, Amandeep S.
Robson, Anthony G.
Bellini, Marco P.
Bloch, Edward
Georgiadis, Odysseas
da Cruz, Lyndon
Bridge, Holly
MacLaren, Robert E.
author_sort Jolly, Jasleen K.
collection PubMed
description Color vision is considered a marker of cone function and its assessment in patients with retinal pathology is complementary to the assessments of spatial vision [best-corrected visual acuity (BCVA)] and contrast detection (perimetry). Rod-cone and chorioretinal dystrophies—such as choroideremia—typically cause alterations to color vision, making its assessment a potential outcome measure in clinical trials. However, clinical evaluation of color vision may be compromised by pathological changes to spatial vision and the visual field. The low vision Cambridge Color Test (lvCCT) was developed specifically to address these latter issues. We used the trivector version of the lvCCT to quantify color discrimination in a cohort of 53 patients with choroideremia. This test enables rapid and precise characterization of color discrimination along protan, deutan, and tritan axes more reliably than the historically preferred test for clinical trials, namely the Farnsworth Munsell 100 Hue test. The lvCCT demonstrates that color vision defects—particularly along the tritan axis—are seen early in choroideremia, and that this occurs independent of changes in visual acuity, pattern electroretinography and ellipsoid zone area on optical coherence tomography (OCT). We argue that the selective loss of tritan color discrimination can be explained by our current understanding of the machinery of color vision and the pathophysiology of choroideremia.
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spelling pubmed-85292112021-10-22 Structural and Functional Characteristics of Color Vision Changes in Choroideremia Jolly, Jasleen K. Simunovic, Matthew P. Dubis, Adam M. Josan, Amandeep S. Robson, Anthony G. Bellini, Marco P. Bloch, Edward Georgiadis, Odysseas da Cruz, Lyndon Bridge, Holly MacLaren, Robert E. Front Neurosci Neuroscience Color vision is considered a marker of cone function and its assessment in patients with retinal pathology is complementary to the assessments of spatial vision [best-corrected visual acuity (BCVA)] and contrast detection (perimetry). Rod-cone and chorioretinal dystrophies—such as choroideremia—typically cause alterations to color vision, making its assessment a potential outcome measure in clinical trials. However, clinical evaluation of color vision may be compromised by pathological changes to spatial vision and the visual field. The low vision Cambridge Color Test (lvCCT) was developed specifically to address these latter issues. We used the trivector version of the lvCCT to quantify color discrimination in a cohort of 53 patients with choroideremia. This test enables rapid and precise characterization of color discrimination along protan, deutan, and tritan axes more reliably than the historically preferred test for clinical trials, namely the Farnsworth Munsell 100 Hue test. The lvCCT demonstrates that color vision defects—particularly along the tritan axis—are seen early in choroideremia, and that this occurs independent of changes in visual acuity, pattern electroretinography and ellipsoid zone area on optical coherence tomography (OCT). We argue that the selective loss of tritan color discrimination can be explained by our current understanding of the machinery of color vision and the pathophysiology of choroideremia. Frontiers Media S.A. 2021-10-07 /pmc/articles/PMC8529211/ /pubmed/34690675 http://dx.doi.org/10.3389/fnins.2021.729807 Text en Copyright © 2021 Jolly, Simunovic, Dubis, Josan, Robson, Bellini, Bloch, Georgiadis, da Cruz, Bridge and MacLaren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jolly, Jasleen K.
Simunovic, Matthew P.
Dubis, Adam M.
Josan, Amandeep S.
Robson, Anthony G.
Bellini, Marco P.
Bloch, Edward
Georgiadis, Odysseas
da Cruz, Lyndon
Bridge, Holly
MacLaren, Robert E.
Structural and Functional Characteristics of Color Vision Changes in Choroideremia
title Structural and Functional Characteristics of Color Vision Changes in Choroideremia
title_full Structural and Functional Characteristics of Color Vision Changes in Choroideremia
title_fullStr Structural and Functional Characteristics of Color Vision Changes in Choroideremia
title_full_unstemmed Structural and Functional Characteristics of Color Vision Changes in Choroideremia
title_short Structural and Functional Characteristics of Color Vision Changes in Choroideremia
title_sort structural and functional characteristics of color vision changes in choroideremia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529211/
https://www.ncbi.nlm.nih.gov/pubmed/34690675
http://dx.doi.org/10.3389/fnins.2021.729807
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