Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss

Sarcomatoid carcinoma of the colon is an extremely rare tumor. To date, less than 50 cases have been reported in the literature. It is rapidly growing, with a high recurrence rate, and has a very poor prognosis. Herein we present a 34-year-old male with a two-month history of weight loss, abdominal...

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Autores principales: Isufi, Mimoza, Jabar Ali, Jamila Begum, Joseph, Deepu, Abugoukh, Tahani M, Ghobriel, Naglaa G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529333/
https://www.ncbi.nlm.nih.gov/pubmed/34703684
http://dx.doi.org/10.7759/cureus.18146
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author Isufi, Mimoza
Jabar Ali, Jamila Begum
Joseph, Deepu
Abugoukh, Tahani M
Ghobriel, Naglaa G
author_facet Isufi, Mimoza
Jabar Ali, Jamila Begum
Joseph, Deepu
Abugoukh, Tahani M
Ghobriel, Naglaa G
author_sort Isufi, Mimoza
collection PubMed
description Sarcomatoid carcinoma of the colon is an extremely rare tumor. To date, less than 50 cases have been reported in the literature. It is rapidly growing, with a high recurrence rate, and has a very poor prognosis. Herein we present a 34-year-old male with a two-month history of weight loss, abdominal distention, and chronic history of constipation. Endoscopy was done and revealed undifferentiated adenocarcinoma of the transverse colon. On histopathology, the tumor was composed of sarcomatous and carcinomatous components. On immunohistochemistry, strong immunoreactivity for cytokeratin was found and the spindle cell component was largely vimentin positive.
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spelling pubmed-85293332021-10-25 Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss Isufi, Mimoza Jabar Ali, Jamila Begum Joseph, Deepu Abugoukh, Tahani M Ghobriel, Naglaa G Cureus Internal Medicine Sarcomatoid carcinoma of the colon is an extremely rare tumor. To date, less than 50 cases have been reported in the literature. It is rapidly growing, with a high recurrence rate, and has a very poor prognosis. Herein we present a 34-year-old male with a two-month history of weight loss, abdominal distention, and chronic history of constipation. Endoscopy was done and revealed undifferentiated adenocarcinoma of the transverse colon. On histopathology, the tumor was composed of sarcomatous and carcinomatous components. On immunohistochemistry, strong immunoreactivity for cytokeratin was found and the spindle cell component was largely vimentin positive. Cureus 2021-09-20 /pmc/articles/PMC8529333/ /pubmed/34703684 http://dx.doi.org/10.7759/cureus.18146 Text en Copyright © 2021, Isufi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Isufi, Mimoza
Jabar Ali, Jamila Begum
Joseph, Deepu
Abugoukh, Tahani M
Ghobriel, Naglaa G
Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss
title Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss
title_full Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss
title_fullStr Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss
title_full_unstemmed Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss
title_short Spindle Cell Carcinoma (Sarcomatoid) of Colon Presenting as Weight Loss
title_sort spindle cell carcinoma (sarcomatoid) of colon presenting as weight loss
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529333/
https://www.ncbi.nlm.nih.gov/pubmed/34703684
http://dx.doi.org/10.7759/cureus.18146
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