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Human microRNA similarity in breast cancer
MicroRNAs (miRNAs) play important roles in a variety of human diseases, including breast cancer. A number of miRNAs are up- and down-regulated in breast cancer. However, little is known about miRNA similarity and similarity network in breast cancer. Here, a collection of 272 breast cancer-associated...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529337/ https://www.ncbi.nlm.nih.gov/pubmed/34612484 http://dx.doi.org/10.1042/BSR20211123 |
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author | Jing, Ying Li, Donghai |
author_facet | Jing, Ying Li, Donghai |
author_sort | Jing, Ying |
collection | PubMed |
description | MicroRNAs (miRNAs) play important roles in a variety of human diseases, including breast cancer. A number of miRNAs are up- and down-regulated in breast cancer. However, little is known about miRNA similarity and similarity network in breast cancer. Here, a collection of 272 breast cancer-associated miRNA precursors (pre-miRNAs) were utilized to calculate similarities of sequences, target genes, pathways and functions and construct a combined similarity network. Well-characterized miRNAs and their similarity network were highlighted. Interestingly, miRNA sequence-dependent similarity networks were not identified in spite of sequence–target gene association. Similarity networks with minimum and maximum number of miRNAs originate from pathway and mature sequence, respectively. The breast cancer-associated miRNAs were divided into seven functional classes (classes I–VII) followed by disease enrichment analysis and novel miRNA-based disease similarities were found. The finding would provide insight into miRNA similarity, similarity network and disease heterogeneity in breast cancer. |
format | Online Article Text |
id | pubmed-8529337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85293372021-11-02 Human microRNA similarity in breast cancer Jing, Ying Li, Donghai Biosci Rep Cancer MicroRNAs (miRNAs) play important roles in a variety of human diseases, including breast cancer. A number of miRNAs are up- and down-regulated in breast cancer. However, little is known about miRNA similarity and similarity network in breast cancer. Here, a collection of 272 breast cancer-associated miRNA precursors (pre-miRNAs) were utilized to calculate similarities of sequences, target genes, pathways and functions and construct a combined similarity network. Well-characterized miRNAs and their similarity network were highlighted. Interestingly, miRNA sequence-dependent similarity networks were not identified in spite of sequence–target gene association. Similarity networks with minimum and maximum number of miRNAs originate from pathway and mature sequence, respectively. The breast cancer-associated miRNAs were divided into seven functional classes (classes I–VII) followed by disease enrichment analysis and novel miRNA-based disease similarities were found. The finding would provide insight into miRNA similarity, similarity network and disease heterogeneity in breast cancer. Portland Press Ltd. 2021-10-19 /pmc/articles/PMC8529337/ /pubmed/34612484 http://dx.doi.org/10.1042/BSR20211123 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Cancer Jing, Ying Li, Donghai Human microRNA similarity in breast cancer |
title | Human microRNA similarity in breast cancer |
title_full | Human microRNA similarity in breast cancer |
title_fullStr | Human microRNA similarity in breast cancer |
title_full_unstemmed | Human microRNA similarity in breast cancer |
title_short | Human microRNA similarity in breast cancer |
title_sort | human microrna similarity in breast cancer |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529337/ https://www.ncbi.nlm.nih.gov/pubmed/34612484 http://dx.doi.org/10.1042/BSR20211123 |
work_keys_str_mv | AT jingying humanmicrornasimilarityinbreastcancer AT lidonghai humanmicrornasimilarityinbreastcancer |