Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG

DNA‐binding proteins, including transcription factors (TFs), play essential roles in various cellular processes and pathogenesis of diseases, deeming to be potential therapeutic targets. However, these proteins are generally considered undruggable as they lack an enzymatic catalytic site or a ligand...

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Detalles Bibliográficos
Autores principales: Shao, Jingwei, Yan, Yuqian, Ding, Donglin, Wang, Dejie, He, Yundong, Pan, Yunqian, Yan, Wei, Kharbanda, Anupreet, Li, Hong‐yu, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529430/
https://www.ncbi.nlm.nih.gov/pubmed/34397171
http://dx.doi.org/10.1002/advs.202102555

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