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Ten Years of EWAS
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next‐generation, and third‐generation sequencing te...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529436/ https://www.ncbi.nlm.nih.gov/pubmed/34382344 http://dx.doi.org/10.1002/advs.202100727 |
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| author | Wei, Siyu Tao, Junxian Xu, Jing Chen, Xingyu Wang, Zhaoyang Zhang, Nan Zuo, Lijiao Jia, Zhe Chen, Haiyan Sun, Hongmei Yan, Yubo Zhang, Mingming Lv, Hongchao Kong, Fanwu Duan, Lian Ma, Ye Liao, Mingzhi Xu, Liangde Feng, Rennan Liu, Guiyou Project, The EWAS Jiang, Yongshuai |
| author_facet | Wei, Siyu Tao, Junxian Xu, Jing Chen, Xingyu Wang, Zhaoyang Zhang, Nan Zuo, Lijiao Jia, Zhe Chen, Haiyan Sun, Hongmei Yan, Yubo Zhang, Mingming Lv, Hongchao Kong, Fanwu Duan, Lian Ma, Ye Liao, Mingzhi Xu, Liangde Feng, Rennan Liu, Guiyou Project, The EWAS Jiang, Yongshuai |
| author_sort | Wei, Siyu |
| collection | PubMed |
| description | Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next‐generation, and third‐generation sequencing technologies have prepared a high‐quality platform for EWAS. Here, the progress of EWAS research is reviewed, its contributions to clinical applications, and mainly describe the achievements of four typical diseases. Finally, the challenges encountered by EWAS and make bold predictions for its future development are presented. |
| format | Online Article Text |
| id | pubmed-8529436 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85294362021-10-27 Ten Years of EWAS Wei, Siyu Tao, Junxian Xu, Jing Chen, Xingyu Wang, Zhaoyang Zhang, Nan Zuo, Lijiao Jia, Zhe Chen, Haiyan Sun, Hongmei Yan, Yubo Zhang, Mingming Lv, Hongchao Kong, Fanwu Duan, Lian Ma, Ye Liao, Mingzhi Xu, Liangde Feng, Rennan Liu, Guiyou Project, The EWAS Jiang, Yongshuai Adv Sci (Weinh) Reviews Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next‐generation, and third‐generation sequencing technologies have prepared a high‐quality platform for EWAS. Here, the progress of EWAS research is reviewed, its contributions to clinical applications, and mainly describe the achievements of four typical diseases. Finally, the challenges encountered by EWAS and make bold predictions for its future development are presented. John Wiley and Sons Inc. 2021-08-11 /pmc/articles/PMC8529436/ /pubmed/34382344 http://dx.doi.org/10.1002/advs.202100727 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Reviews Wei, Siyu Tao, Junxian Xu, Jing Chen, Xingyu Wang, Zhaoyang Zhang, Nan Zuo, Lijiao Jia, Zhe Chen, Haiyan Sun, Hongmei Yan, Yubo Zhang, Mingming Lv, Hongchao Kong, Fanwu Duan, Lian Ma, Ye Liao, Mingzhi Xu, Liangde Feng, Rennan Liu, Guiyou Project, The EWAS Jiang, Yongshuai Ten Years of EWAS |
| title | Ten Years of EWAS |
| title_full | Ten Years of EWAS |
| title_fullStr | Ten Years of EWAS |
| title_full_unstemmed | Ten Years of EWAS |
| title_short | Ten Years of EWAS |
| title_sort | ten years of ewas |
| topic | Reviews |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529436/ https://www.ncbi.nlm.nih.gov/pubmed/34382344 http://dx.doi.org/10.1002/advs.202100727 |
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