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KAT6A Acetylation of SMAD3 Regulates Myeloid‐Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple‐Negative Breast Cancer
Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, SMAD3 is identified as a nonhistone substrate of lysine acetyltransferase 6A (KAT6A). The acetylation of SMAD3 at K20 and K117 by KAT6A promotes SMAD3 associa...
Autores principales: | Yu, Bo, Luo, Fei, Sun, Bowen, Liu, Wenxue, Shi, Qiqi, Cheng, Shi‐Yuan, Chen, Ceshi, Chen, Guoqiang, Li, Yanxin, Feng, Haizhong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529494/ https://www.ncbi.nlm.nih.gov/pubmed/34392614 http://dx.doi.org/10.1002/advs.202100014 |
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