KAT6A Acetylation of SMAD3 Regulates Myeloid‐Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple‐Negative Breast Cancer

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Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, SMAD3 is identified as a nonhistone substrate of lysine acetyltransferase 6A (KAT6A). The acetylation of SMAD3 at K20 and K117 by KAT6A promotes SMAD3 associa...

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Detalles Bibliográficos
Autores principales: Yu, Bo, Luo, Fei, Sun, Bowen, Liu, Wenxue, Shi, Qiqi, Cheng, Shi‐Yuan, Chen, Ceshi, Chen, Guoqiang, Li, Yanxin, Feng, Haizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529494/
https://www.ncbi.nlm.nih.gov/pubmed/34392614
http://dx.doi.org/10.1002/advs.202100014
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