Pharmacological blockade of the EP3 prostaglandin E(2) receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage

OBJECTIVE: Type 2 diabetes is characterized by hyperglycemia and inflammation. Prostaglandin E(2), which signals through four G protein-coupled receptors (EP1-4), is a mediator of inflammation and is upregulated in diabetes. We have shown previously that EP3 receptor blockade promotes β-cell prolife...

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Detalles Bibliográficos
Autores principales: Bosma, Karin J., Andrei, Spencer R., Katz, Liora S., Smith, Ashley A., Dunn, Jennifer C., Ricciardi, Valerie F., Ramirez, Marisol A., Baumel-Alterzon, Sharon, Pace, William A., Carroll, Darian T., Overway, Emily M., Wolf, Elysa M., Kimple, Michelle E., Sheng, Quanhu, Scott, Donald K., Breyer, Richard M., Gannon, Maureen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529552/
https://www.ncbi.nlm.nih.gov/pubmed/34626853
http://dx.doi.org/10.1016/j.molmet.2021.101347

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