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Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa

BACKGROUND: Withania somnifera (L.) Dunal (W. somnifera) is a herb commonly known by its English name as Winter Cherry. Africa is indigenous to many medicinal plants and natural products. However, there is inadequate documentation of medicinal plants, including W. somnifera, in Africa. There is, the...

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Autores principales: Afewerky, Henok Kessete, Ayodeji, Ayeni Emmanuel, Tiamiyu, Bashir Bolaji, Orege, Joshua Iseoluwa, Okeke, Emmanuel Sunday, Oyejobi, Aanuoluwapo Opeyemi, Bate, Petuel Ndip Ndip, Adeyemi, Sherif Babatunde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529567/
https://www.ncbi.nlm.nih.gov/pubmed/34697529
http://dx.doi.org/10.1186/s42269-021-00635-6
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author Afewerky, Henok Kessete
Ayodeji, Ayeni Emmanuel
Tiamiyu, Bashir Bolaji
Orege, Joshua Iseoluwa
Okeke, Emmanuel Sunday
Oyejobi, Aanuoluwapo Opeyemi
Bate, Petuel Ndip Ndip
Adeyemi, Sherif Babatunde
author_facet Afewerky, Henok Kessete
Ayodeji, Ayeni Emmanuel
Tiamiyu, Bashir Bolaji
Orege, Joshua Iseoluwa
Okeke, Emmanuel Sunday
Oyejobi, Aanuoluwapo Opeyemi
Bate, Petuel Ndip Ndip
Adeyemi, Sherif Babatunde
author_sort Afewerky, Henok Kessete
collection PubMed
description BACKGROUND: Withania somnifera (L.) Dunal (W. somnifera) is a herb commonly known by its English name as Winter Cherry. Africa is indigenous to many medicinal plants and natural products. However, there is inadequate documentation of medicinal plants, including W. somnifera, in Africa. There is, therefore, a need for a comprehensive compilation of research outcomes of this reviewed plant as used in traditional medicine in different regions of Africa. METHODOLOGY: Scientific articles and publications were scooped and sourced from high-impact factor journals and filtered with relevant keywords on W. somnifera. Scientific databases, including GBIF, PubMed, NCBI, Google Scholar, Research Gate, Science Direct, SciFinder, and Web of Science, were accessed to identify the most influential articles and recent breakthroughs published on the contexts of ethnography, ethnomedicinal uses, phytochemistry, pharmacology, and commercialization of W. somnifera. RESULTS: This critical review covers the W. somnifera ethnography, phytochemistry, and ethnomedicinal usage to demonstrate the use of the plant in Africa and elsewhere to prevent or alleviate several pathophysiological conditions, including cardiovascular, neurodegenerative, reproductive impotence, as well as other chronic diseases. CONCLUSION: W. somnifera is reportedly safe for administration in ethnomedicine as several research outcomes confirmed its safety status. The significance of commercializing this plant in Africa for drug development is herein thoroughly covered to provide the much-needed highlights towards its cultivations economic benefit to Africa.
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spelling pubmed-85295672021-10-21 Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa Afewerky, Henok Kessete Ayodeji, Ayeni Emmanuel Tiamiyu, Bashir Bolaji Orege, Joshua Iseoluwa Okeke, Emmanuel Sunday Oyejobi, Aanuoluwapo Opeyemi Bate, Petuel Ndip Ndip Adeyemi, Sherif Babatunde Bull Natl Res Cent Review BACKGROUND: Withania somnifera (L.) Dunal (W. somnifera) is a herb commonly known by its English name as Winter Cherry. Africa is indigenous to many medicinal plants and natural products. However, there is inadequate documentation of medicinal plants, including W. somnifera, in Africa. There is, therefore, a need for a comprehensive compilation of research outcomes of this reviewed plant as used in traditional medicine in different regions of Africa. METHODOLOGY: Scientific articles and publications were scooped and sourced from high-impact factor journals and filtered with relevant keywords on W. somnifera. Scientific databases, including GBIF, PubMed, NCBI, Google Scholar, Research Gate, Science Direct, SciFinder, and Web of Science, were accessed to identify the most influential articles and recent breakthroughs published on the contexts of ethnography, ethnomedicinal uses, phytochemistry, pharmacology, and commercialization of W. somnifera. RESULTS: This critical review covers the W. somnifera ethnography, phytochemistry, and ethnomedicinal usage to demonstrate the use of the plant in Africa and elsewhere to prevent or alleviate several pathophysiological conditions, including cardiovascular, neurodegenerative, reproductive impotence, as well as other chronic diseases. CONCLUSION: W. somnifera is reportedly safe for administration in ethnomedicine as several research outcomes confirmed its safety status. The significance of commercializing this plant in Africa for drug development is herein thoroughly covered to provide the much-needed highlights towards its cultivations economic benefit to Africa. Springer Berlin Heidelberg 2021-10-21 2021 /pmc/articles/PMC8529567/ /pubmed/34697529 http://dx.doi.org/10.1186/s42269-021-00635-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Afewerky, Henok Kessete
Ayodeji, Ayeni Emmanuel
Tiamiyu, Bashir Bolaji
Orege, Joshua Iseoluwa
Okeke, Emmanuel Sunday
Oyejobi, Aanuoluwapo Opeyemi
Bate, Petuel Ndip Ndip
Adeyemi, Sherif Babatunde
Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
title Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
title_full Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
title_fullStr Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
title_full_unstemmed Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
title_short Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
title_sort critical review of the withania somnifera (l.) dunal: ethnobotany, pharmacological efficacy, and commercialization significance in africa
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529567/
https://www.ncbi.nlm.nih.gov/pubmed/34697529
http://dx.doi.org/10.1186/s42269-021-00635-6
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