A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

The AMP-activated protein kinase (Ampk) is a central regulator of metabolic pathways and increasing Ampk activity has been considered to be an attractive therapeutic target. Here, we identified an orphan ubiquitin E3 ligase subunit protein, Fbxo48, that targets the active, phosphorylated Ampkα (pAmp...

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Detalles Bibliográficos
Autores principales: Liu, Yuan, Jurczak, Michael J., Lear, Travis B., Lin, Bo, Larsen, Mads B., Kennerdell, Jason R., Chen, Yanwen, Huckestein, Brydie R., Nguyen, Matthew K., Tuncer, Ferhan, Jiang, Yu, Monga, Satdarshan P., O’Donnell, Christopher P., Finkel, Toren, Chen, Bill B., Mallampalli, Rama K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529588/
https://www.ncbi.nlm.nih.gov/pubmed/33495648
http://dx.doi.org/10.1038/s41589-020-00723-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529588/
https://www.ncbi.nlm.nih.gov/pubmed/33495648
http://dx.doi.org/10.1038/s41589-020-00723-0

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