Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking

[Image: see text] Compound Danshen dropping pill (CDDP), a famous Chinese medicine formula, has been widely used to treat high-altitude heart disease in China. However, its molecular mechanisms, potential targets, and bioactive ingredients remain elusive. In this study, network pharmacology, molecul...

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Detalles Bibliográficos
Autores principales: Yan, Jiayi, Ruan, Panpan, Ge, Yunxuan, Gao, Jing, Tan, Hongling, Xiao, Chengrong, Gao, Quansheng, Zhang, Zhuo, Gao, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529605/
https://www.ncbi.nlm.nih.gov/pubmed/34693115
http://dx.doi.org/10.1021/acsomega.1c03282
Descripción
Sumario:[Image: see text] Compound Danshen dropping pill (CDDP), a famous Chinese medicine formula, has been widely used to treat high-altitude heart disease in China. However, its molecular mechanisms, potential targets, and bioactive ingredients remain elusive. In this study, network pharmacology, molecular docking, and validation experiments were combined to investigate the effective active ingredients and molecular mechanisms of CDDP in the treatment of high-altitude heart disease. Tan IIA may be the main active component of CDDP in the treatment of high-altitude heart disease via HIF-1/PI3K/Akt pathways.

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