Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking

[Image: see text] Compound Danshen dropping pill (CDDP), a famous Chinese medicine formula, has been widely used to treat high-altitude heart disease in China. However, its molecular mechanisms, potential targets, and bioactive ingredients remain elusive. In this study, network pharmacology, molecul...

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Autores principales: Yan, Jiayi, Ruan, Panpan, Ge, Yunxuan, Gao, Jing, Tan, Hongling, Xiao, Chengrong, Gao, Quansheng, Zhang, Zhuo, Gao, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529605/
https://www.ncbi.nlm.nih.gov/pubmed/34693115
http://dx.doi.org/10.1021/acsomega.1c03282
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author Yan, Jiayi
Ruan, Panpan
Ge, Yunxuan
Gao, Jing
Tan, Hongling
Xiao, Chengrong
Gao, Quansheng
Zhang, Zhuo
Gao, Yue
author_facet Yan, Jiayi
Ruan, Panpan
Ge, Yunxuan
Gao, Jing
Tan, Hongling
Xiao, Chengrong
Gao, Quansheng
Zhang, Zhuo
Gao, Yue
author_sort Yan, Jiayi
collection PubMed
description [Image: see text] Compound Danshen dropping pill (CDDP), a famous Chinese medicine formula, has been widely used to treat high-altitude heart disease in China. However, its molecular mechanisms, potential targets, and bioactive ingredients remain elusive. In this study, network pharmacology, molecular docking, and validation experiments were combined to investigate the effective active ingredients and molecular mechanisms of CDDP in the treatment of high-altitude heart disease. Tan IIA may be the main active component of CDDP in the treatment of high-altitude heart disease via HIF-1/PI3K/Akt pathways.
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spelling pubmed-85296052021-10-22 Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking Yan, Jiayi Ruan, Panpan Ge, Yunxuan Gao, Jing Tan, Hongling Xiao, Chengrong Gao, Quansheng Zhang, Zhuo Gao, Yue ACS Omega [Image: see text] Compound Danshen dropping pill (CDDP), a famous Chinese medicine formula, has been widely used to treat high-altitude heart disease in China. However, its molecular mechanisms, potential targets, and bioactive ingredients remain elusive. In this study, network pharmacology, molecular docking, and validation experiments were combined to investigate the effective active ingredients and molecular mechanisms of CDDP in the treatment of high-altitude heart disease. Tan IIA may be the main active component of CDDP in the treatment of high-altitude heart disease via HIF-1/PI3K/Akt pathways. American Chemical Society 2021-10-05 /pmc/articles/PMC8529605/ /pubmed/34693115 http://dx.doi.org/10.1021/acsomega.1c03282 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Yan, Jiayi
Ruan, Panpan
Ge, Yunxuan
Gao, Jing
Tan, Hongling
Xiao, Chengrong
Gao, Quansheng
Zhang, Zhuo
Gao, Yue
Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
title Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
title_full Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
title_fullStr Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
title_full_unstemmed Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
title_short Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
title_sort mechanisms and molecular targets of compound danshen dropping pill for heart disease caused by high altitude based on network pharmacology and molecular docking
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529605/
https://www.ncbi.nlm.nih.gov/pubmed/34693115
http://dx.doi.org/10.1021/acsomega.1c03282
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