Cargando…
Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned
BACKGROUND: COVID-19 pandemic has globally affected healthcare including the transplantation programmes. MATERIALS AND METHODS: We retrospectively studied the impact of COVID-19 on live liver donor (LLD) programme at liver transplant centre in Gambat, Pakistan. Standard operative procedures (SOPs) i...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529618/ https://www.ncbi.nlm.nih.gov/pubmed/34670755 http://dx.doi.org/10.1136/bmjgast-2021-000723 |
_version_ | 1784586506810163200 |
---|---|
author | Dogar, Abdul Wahab Uddin, Shams Ghaffar, Abdul Abbas, Syed Hasnain Izzo, Hala Hussain, Azhar Ullah, Kaleem Shoaib, Azam Ud Din, Siraj Ahmed, Bilal Hamza, Muhammad Ameer Zafar, Munaza Qaiser, Muhammad Affan Raza, Hamid Baig, Muhammad Asif Husnain, Ali Mumtaz, Khalid |
author_facet | Dogar, Abdul Wahab Uddin, Shams Ghaffar, Abdul Abbas, Syed Hasnain Izzo, Hala Hussain, Azhar Ullah, Kaleem Shoaib, Azam Ud Din, Siraj Ahmed, Bilal Hamza, Muhammad Ameer Zafar, Munaza Qaiser, Muhammad Affan Raza, Hamid Baig, Muhammad Asif Husnain, Ali Mumtaz, Khalid |
author_sort | Dogar, Abdul Wahab |
collection | PubMed |
description | BACKGROUND: COVID-19 pandemic has globally affected healthcare including the transplantation programmes. MATERIALS AND METHODS: We retrospectively studied the impact of COVID-19 on live liver donor (LLD) programme at liver transplant centre in Gambat, Pakistan. Standard operative procedures (SOPs) including COVID-19 nasopharyngeal swab PCR, CT scans, personal protective equipment use, 6-feet distancing were developed for LLD and transplant team to mitigate COVID-19 exposure. We compared the complications, healthcare utilisation (hospital stay, readmission) and mortality between two LLD cohorts—before and during COVID-19 pandemic from March 2019 to December 2020. RESULTS: During study period 300 LLD surgeries were performed. There was an increase in rate of LLDs from 132 (44%) in pre-COVID to 168 (56%) during COVID-19 era. Average numbers of transplants per month performed during pre-COVID and during COVID-19 era were 10.1 and 14, respectively. No donor has developed COVID-19 infection during hospitalisation. Rate of all LLD complications (32 (21.47%) and 49 (29.16%), p=0.43), uneventful discharges (120/168 (71.4%) and 88/132 (66.6%), p<0.05), mean hospital stay (6±2 days and 5±2 days, p=0.17) and readmission (5 (4%) and 3 (1.8%), p=0.43) were similar during the pre-COVID and COVID-19 era. No donor mortality was observed during study period. CONCLUSION: With the implementation of mindful SOPs, rate of LLD increased without any case of COVID-19 infection. Our SOPs were helpful in continuation of LLD programme in a developing country during COVID-19 pandemic. |
format | Online Article Text |
id | pubmed-8529618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-85296182021-10-21 Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned Dogar, Abdul Wahab Uddin, Shams Ghaffar, Abdul Abbas, Syed Hasnain Izzo, Hala Hussain, Azhar Ullah, Kaleem Shoaib, Azam Ud Din, Siraj Ahmed, Bilal Hamza, Muhammad Ameer Zafar, Munaza Qaiser, Muhammad Affan Raza, Hamid Baig, Muhammad Asif Husnain, Ali Mumtaz, Khalid BMJ Open Gastroenterol Hepatology BACKGROUND: COVID-19 pandemic has globally affected healthcare including the transplantation programmes. MATERIALS AND METHODS: We retrospectively studied the impact of COVID-19 on live liver donor (LLD) programme at liver transplant centre in Gambat, Pakistan. Standard operative procedures (SOPs) including COVID-19 nasopharyngeal swab PCR, CT scans, personal protective equipment use, 6-feet distancing were developed for LLD and transplant team to mitigate COVID-19 exposure. We compared the complications, healthcare utilisation (hospital stay, readmission) and mortality between two LLD cohorts—before and during COVID-19 pandemic from March 2019 to December 2020. RESULTS: During study period 300 LLD surgeries were performed. There was an increase in rate of LLDs from 132 (44%) in pre-COVID to 168 (56%) during COVID-19 era. Average numbers of transplants per month performed during pre-COVID and during COVID-19 era were 10.1 and 14, respectively. No donor has developed COVID-19 infection during hospitalisation. Rate of all LLD complications (32 (21.47%) and 49 (29.16%), p=0.43), uneventful discharges (120/168 (71.4%) and 88/132 (66.6%), p<0.05), mean hospital stay (6±2 days and 5±2 days, p=0.17) and readmission (5 (4%) and 3 (1.8%), p=0.43) were similar during the pre-COVID and COVID-19 era. No donor mortality was observed during study period. CONCLUSION: With the implementation of mindful SOPs, rate of LLD increased without any case of COVID-19 infection. Our SOPs were helpful in continuation of LLD programme in a developing country during COVID-19 pandemic. BMJ Publishing Group 2021-10-20 /pmc/articles/PMC8529618/ /pubmed/34670755 http://dx.doi.org/10.1136/bmjgast-2021-000723 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Hepatology Dogar, Abdul Wahab Uddin, Shams Ghaffar, Abdul Abbas, Syed Hasnain Izzo, Hala Hussain, Azhar Ullah, Kaleem Shoaib, Azam Ud Din, Siraj Ahmed, Bilal Hamza, Muhammad Ameer Zafar, Munaza Qaiser, Muhammad Affan Raza, Hamid Baig, Muhammad Asif Husnain, Ali Mumtaz, Khalid Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned |
title | Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned |
title_full | Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned |
title_fullStr | Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned |
title_full_unstemmed | Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned |
title_short | Challenges of continuation of live liver donor programme during COVID-19 pandemic in Pakistan: outcomes and lessons learned |
title_sort | challenges of continuation of live liver donor programme during covid-19 pandemic in pakistan: outcomes and lessons learned |
topic | Hepatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529618/ https://www.ncbi.nlm.nih.gov/pubmed/34670755 http://dx.doi.org/10.1136/bmjgast-2021-000723 |
work_keys_str_mv | AT dogarabdulwahab challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT uddinshams challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT ghaffarabdul challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT abbassyedhasnain challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT izzohala challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT hussainazhar challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT ullahkaleem challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT shoaibazam challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT uddinsiraj challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT ahmedbilal challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT hamzamuhammadameer challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT zafarmunaza challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT qaisermuhammadaffan challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT razahamid challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT baigmuhammadasif challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT husnainali challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned AT mumtazkhalid challengesofcontinuationofliveliverdonorprogrammeduringcovid19pandemicinpakistanoutcomesandlessonslearned |