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Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China
BACKGROUND: Comorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of a stroke. However, the association of pre-existing comorbidities with stroke risk has not been fully studied. METHODS: This study included 16,246 adults from a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529731/ https://www.ncbi.nlm.nih.gov/pubmed/34674693 http://dx.doi.org/10.1186/s12889-021-12002-1 |
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author | Zhang, Ya Wang, Cuicui Liu, Dong Zhou, Zhengyuan Gu, Shujun Zuo, Hui |
author_facet | Zhang, Ya Wang, Cuicui Liu, Dong Zhou, Zhengyuan Gu, Shujun Zuo, Hui |
author_sort | Zhang, Ya |
collection | PubMed |
description | BACKGROUND: Comorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of a stroke. However, the association of pre-existing comorbidities with stroke risk has not been fully studied. METHODS: This study included 16,246 adults from a prospective community-based cohort with a baseline survey conducted in 2013 in China. Participants were followed up with hospitalization records and the Cause of Death Registry. The association of eight pre-existing comorbidities (coronary heart disease, hyperlipidemia, hypertension, diabetes, previous stroke, chronic obstructive pulmonary disease, nephropathy, and cancer) with stroke risk was analyzed using the Cox proportional hazard model in 2020. RESULTS: At a median follow-up of 5.5 years, a total of 449 participants (206 men and 243 women) developed a stroke. Four pre-existing comorbidities (hypertension, congenital heart disease, previous stroke, and diabetes) were independently and positively associated with the risk for all types of stroke. The adjusted hazard ratios for participants with only 1 and ≥ 2 pre-existing comorbidities compared with those without pre-existing conditions were 1.96 (95% CI: 1.44, 2.67; P < 0.001) and 2.87 (95% CI; 2.09, 3.94; P < 0.001) for total stroke, respectively. Moreover, male and female participants with a combination of increased age and a higher number of pre-existing comorbidities experienced the greatest risk of stroke. CONCLUSIONS: The number of pre-existing comorbidities was independently associated with an increased risk of stroke. There was a synergic effect between increased age and a higher number of pre-existing comorbidities on stroke occurrence. Our novel findings emphasize the importance and potential application of pre-existing comorbidities as a risk indicator in stroke prevention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-021-12002-1. |
format | Online Article Text |
id | pubmed-8529731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85297312021-10-25 Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China Zhang, Ya Wang, Cuicui Liu, Dong Zhou, Zhengyuan Gu, Shujun Zuo, Hui BMC Public Health Research BACKGROUND: Comorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of a stroke. However, the association of pre-existing comorbidities with stroke risk has not been fully studied. METHODS: This study included 16,246 adults from a prospective community-based cohort with a baseline survey conducted in 2013 in China. Participants were followed up with hospitalization records and the Cause of Death Registry. The association of eight pre-existing comorbidities (coronary heart disease, hyperlipidemia, hypertension, diabetes, previous stroke, chronic obstructive pulmonary disease, nephropathy, and cancer) with stroke risk was analyzed using the Cox proportional hazard model in 2020. RESULTS: At a median follow-up of 5.5 years, a total of 449 participants (206 men and 243 women) developed a stroke. Four pre-existing comorbidities (hypertension, congenital heart disease, previous stroke, and diabetes) were independently and positively associated with the risk for all types of stroke. The adjusted hazard ratios for participants with only 1 and ≥ 2 pre-existing comorbidities compared with those without pre-existing conditions were 1.96 (95% CI: 1.44, 2.67; P < 0.001) and 2.87 (95% CI; 2.09, 3.94; P < 0.001) for total stroke, respectively. Moreover, male and female participants with a combination of increased age and a higher number of pre-existing comorbidities experienced the greatest risk of stroke. CONCLUSIONS: The number of pre-existing comorbidities was independently associated with an increased risk of stroke. There was a synergic effect between increased age and a higher number of pre-existing comorbidities on stroke occurrence. Our novel findings emphasize the importance and potential application of pre-existing comorbidities as a risk indicator in stroke prevention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-021-12002-1. BioMed Central 2021-10-21 /pmc/articles/PMC8529731/ /pubmed/34674693 http://dx.doi.org/10.1186/s12889-021-12002-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhang, Ya Wang, Cuicui Liu, Dong Zhou, Zhengyuan Gu, Shujun Zuo, Hui Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
title | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
title_full | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
title_fullStr | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
title_full_unstemmed | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
title_short | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
title_sort | association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from china |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529731/ https://www.ncbi.nlm.nih.gov/pubmed/34674693 http://dx.doi.org/10.1186/s12889-021-12002-1 |
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