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Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis

BACKGROUND: Lower prognostic nutritional index (PNI) is related to the poor prognosis of cardiovascular diseases. However, little is known about PNI and its relationship with the prognosis of cerebral venous sinus thrombosis (CVST). METHODS: CVST patients were retrospectively identified from January...

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Autores principales: Zhao, Jiawei, Liu, Kai, Li, Shen, Gao, Yuan, Zhao, Lu, Liu, Hongbing, Fang, Hui, Wu, Jun, Sun, Shilei, Li, Yusheng, Song, Bo, Xu, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529735/
https://www.ncbi.nlm.nih.gov/pubmed/34674659
http://dx.doi.org/10.1186/s12883-021-02436-w
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author Zhao, Jiawei
Liu, Kai
Li, Shen
Gao, Yuan
Zhao, Lu
Liu, Hongbing
Fang, Hui
Wu, Jun
Sun, Shilei
Li, Yusheng
Song, Bo
Xu, Yuming
author_facet Zhao, Jiawei
Liu, Kai
Li, Shen
Gao, Yuan
Zhao, Lu
Liu, Hongbing
Fang, Hui
Wu, Jun
Sun, Shilei
Li, Yusheng
Song, Bo
Xu, Yuming
author_sort Zhao, Jiawei
collection PubMed
description BACKGROUND: Lower prognostic nutritional index (PNI) is related to the poor prognosis of cardiovascular diseases. However, little is known about PNI and its relationship with the prognosis of cerebral venous sinus thrombosis (CVST). METHODS: CVST patients were retrospectively identified from January 2013 till June 2019. Patients in the acute / subacute phase were selected as subjects. Poor prognosis was defined as a modified Rankin Scale (mRS) of 3–6. Multivariate logistic regression analysis was used to confirm if lower PNI was associated with a poor prognosis. RESULTS: A total of 297 subjects with follow-up data were enrolled. Thirty-three (11.1%) had a poor outcome. Multivariate logistic regression analysis suggested that PNI was an important predictive factor of poor outcome in acute/subacute CVST (odds ratio, 0.903; 95% CI, 0.833–0.978; P = 0.012). The optimal cut-off value for predicting the poor prognosis of PNI was 44.2. Kaplan-Meier analysis and log-rank test suggested that the lower the PNI value, the higher the mortality rate (P < 0.001). In addition, the nomogram that was set up showed that lower PNI was an index of poor prognosis. The c-index for acute/subacute patients with CVST was 0.872. CONCLUSION: Lower PNI is correlated with a higher risk of adverse clinical outcomes in patients with acute/subacute CVST. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-021-02436-w.
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spelling pubmed-85297352021-10-25 Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis Zhao, Jiawei Liu, Kai Li, Shen Gao, Yuan Zhao, Lu Liu, Hongbing Fang, Hui Wu, Jun Sun, Shilei Li, Yusheng Song, Bo Xu, Yuming BMC Neurol Research BACKGROUND: Lower prognostic nutritional index (PNI) is related to the poor prognosis of cardiovascular diseases. However, little is known about PNI and its relationship with the prognosis of cerebral venous sinus thrombosis (CVST). METHODS: CVST patients were retrospectively identified from January 2013 till June 2019. Patients in the acute / subacute phase were selected as subjects. Poor prognosis was defined as a modified Rankin Scale (mRS) of 3–6. Multivariate logistic regression analysis was used to confirm if lower PNI was associated with a poor prognosis. RESULTS: A total of 297 subjects with follow-up data were enrolled. Thirty-three (11.1%) had a poor outcome. Multivariate logistic regression analysis suggested that PNI was an important predictive factor of poor outcome in acute/subacute CVST (odds ratio, 0.903; 95% CI, 0.833–0.978; P = 0.012). The optimal cut-off value for predicting the poor prognosis of PNI was 44.2. Kaplan-Meier analysis and log-rank test suggested that the lower the PNI value, the higher the mortality rate (P < 0.001). In addition, the nomogram that was set up showed that lower PNI was an index of poor prognosis. The c-index for acute/subacute patients with CVST was 0.872. CONCLUSION: Lower PNI is correlated with a higher risk of adverse clinical outcomes in patients with acute/subacute CVST. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-021-02436-w. BioMed Central 2021-10-21 /pmc/articles/PMC8529735/ /pubmed/34674659 http://dx.doi.org/10.1186/s12883-021-02436-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhao, Jiawei
Liu, Kai
Li, Shen
Gao, Yuan
Zhao, Lu
Liu, Hongbing
Fang, Hui
Wu, Jun
Sun, Shilei
Li, Yusheng
Song, Bo
Xu, Yuming
Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis
title Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis
title_full Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis
title_fullStr Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis
title_full_unstemmed Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis
title_short Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis
title_sort prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529735/
https://www.ncbi.nlm.nih.gov/pubmed/34674659
http://dx.doi.org/10.1186/s12883-021-02436-w
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