FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance

Fgf21 (fibroblast growth factor 21) is a regulatory hepatokine that, in pharmacologic form, powerfully promotes weight loss and glucose homeostasis. Although “Fgf21 resistance” is inferred from higher plasma Fgf21 levels in insulin-resistant mice and humans, diminished Fgf21 function is understood p...

Descripción completa

Detalles Bibliográficos
Autores principales: Stöhr, Oliver, Tao, Rongya, Miao, Ji, Copps, Kyle D., White, Morris F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529953/
https://www.ncbi.nlm.nih.gov/pubmed/33761350
http://dx.doi.org/10.1016/j.celrep.2021.108893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529953/
https://www.ncbi.nlm.nih.gov/pubmed/33761350
http://dx.doi.org/10.1016/j.celrep.2021.108893

Ejemplares similares