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Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders

BACKGROUND: Clinical diagnosis of vesiculobullous disorders (VBD) is not always straightforward. It is a challenge for a dermatologist to make the right diagnosis noninvasively in a short time. OBJECTIVE: To evaluate dermoscopic patterns associated with vesiculobullous disorders. METHODS: A total of...

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Autores principales: Narkhede, Namita D., Nikham, Balakrishna, Jamale, Varsha, Hussain, Asma, Kale, Mohan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530039/
https://www.ncbi.nlm.nih.gov/pubmed/34759418
http://dx.doi.org/10.4103/ijd.IJD_294_20
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author Narkhede, Namita D.
Nikham, Balakrishna
Jamale, Varsha
Hussain, Asma
Kale, Mohan
author_facet Narkhede, Namita D.
Nikham, Balakrishna
Jamale, Varsha
Hussain, Asma
Kale, Mohan
author_sort Narkhede, Namita D.
collection PubMed
description BACKGROUND: Clinical diagnosis of vesiculobullous disorders (VBD) is not always straightforward. It is a challenge for a dermatologist to make the right diagnosis noninvasively in a short time. OBJECTIVE: To evaluate dermoscopic patterns associated with vesiculobullous disorders. METHODS: A total of 230 patients, irrespective of age and gender, with a history and clinical presentation suggestive of VBD (including primarily infectious, inflammatory, genetic, antibody-mediated, mechanical, environmental, metabolic, and drug-related) were recruited into the study. Patients with secondarily infected lesions were excluded. Dermoscopic examination along with Tzanck smear/skin biopsy smear test was performed on the most representative lesions. Data were compiled and statistically analyzed using SPSS version 21.0. RESULTS: Lesions with erythematous (vascular) and yellowish (serum) translucent background with regular margins were seen in most of the VBD studied. Chickenpox (CP) and herpes zoster (HZ) lesions evolved with the progress of their clinical stages. Follicular and eccrine openings were commonly seen, but the pigmentation around them was specific to pemphigus vulgaris. A distorted pigment network was noted in bullous pemphigoid. White rosettes (keratin blockage) were characteristic of epidermolysis bullosa, Wickham striae (orthokeratosis) of lichen planus, and crumpled fabric appearance (flaccidity) of Hailey-Hailey disease. Globules/dots (microvesicles) of different colors were also seen in various VBD. Blue/black color usually corresponded to retained melanin. CONCLUSION: Some dermoscopic patterns are observed consistently with certain diseases, and these can be used for their diagnosis, complementary to histopathological examination.
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spelling pubmed-85300392021-11-09 Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders Narkhede, Namita D. Nikham, Balakrishna Jamale, Varsha Hussain, Asma Kale, Mohan Indian J Dermatol Original Article BACKGROUND: Clinical diagnosis of vesiculobullous disorders (VBD) is not always straightforward. It is a challenge for a dermatologist to make the right diagnosis noninvasively in a short time. OBJECTIVE: To evaluate dermoscopic patterns associated with vesiculobullous disorders. METHODS: A total of 230 patients, irrespective of age and gender, with a history and clinical presentation suggestive of VBD (including primarily infectious, inflammatory, genetic, antibody-mediated, mechanical, environmental, metabolic, and drug-related) were recruited into the study. Patients with secondarily infected lesions were excluded. Dermoscopic examination along with Tzanck smear/skin biopsy smear test was performed on the most representative lesions. Data were compiled and statistically analyzed using SPSS version 21.0. RESULTS: Lesions with erythematous (vascular) and yellowish (serum) translucent background with regular margins were seen in most of the VBD studied. Chickenpox (CP) and herpes zoster (HZ) lesions evolved with the progress of their clinical stages. Follicular and eccrine openings were commonly seen, but the pigmentation around them was specific to pemphigus vulgaris. A distorted pigment network was noted in bullous pemphigoid. White rosettes (keratin blockage) were characteristic of epidermolysis bullosa, Wickham striae (orthokeratosis) of lichen planus, and crumpled fabric appearance (flaccidity) of Hailey-Hailey disease. Globules/dots (microvesicles) of different colors were also seen in various VBD. Blue/black color usually corresponded to retained melanin. CONCLUSION: Some dermoscopic patterns are observed consistently with certain diseases, and these can be used for their diagnosis, complementary to histopathological examination. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8530039/ /pubmed/34759418 http://dx.doi.org/10.4103/ijd.IJD_294_20 Text en Copyright: © 2021 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Narkhede, Namita D.
Nikham, Balakrishna
Jamale, Varsha
Hussain, Asma
Kale, Mohan
Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders
title Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders
title_full Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders
title_fullStr Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders
title_full_unstemmed Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders
title_short Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders
title_sort evaluation of dermoscopic patterns of vesiculobullous disorders
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530039/
https://www.ncbi.nlm.nih.gov/pubmed/34759418
http://dx.doi.org/10.4103/ijd.IJD_294_20
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