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Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain

The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies...

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Autores principales: Ritala, Joel F., Lyne, Seán B., Sajanti, Antti, Girard, Romuald, Koskimäki, Janne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530109/
https://www.ncbi.nlm.nih.gov/pubmed/34472454
http://dx.doi.org/10.4103/1673-5374.314291
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author Ritala, Joel F.
Lyne, Seán B.
Sajanti, Antti
Girard, Romuald
Koskimäki, Janne
author_facet Ritala, Joel F.
Lyne, Seán B.
Sajanti, Antti
Girard, Romuald
Koskimäki, Janne
author_sort Ritala, Joel F.
collection PubMed
description The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies highlight the role of p75 neurotrophin receptor (p75(NTR)) in various injuries and diseases such as central nervous system injuries, Alzheimer’s disease and amyotrophic lateral sclerosis. More comprehensive elucidation of the mechanisms, and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury. Due to a diverse role of the p75(NTR) in biology, the body of evidence comprising its biological role is diffusely spread out over numerous fields. This review condenses the main evidence of p75(NTR) for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level.
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spelling pubmed-85301092021-11-09 Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain Ritala, Joel F. Lyne, Seán B. Sajanti, Antti Girard, Romuald Koskimäki, Janne Neural Regen Res Review The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies highlight the role of p75 neurotrophin receptor (p75(NTR)) in various injuries and diseases such as central nervous system injuries, Alzheimer’s disease and amyotrophic lateral sclerosis. More comprehensive elucidation of the mechanisms, and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury. Due to a diverse role of the p75(NTR) in biology, the body of evidence comprising its biological role is diffusely spread out over numerous fields. This review condenses the main evidence of p75(NTR) for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level. Wolters Kluwer - Medknow 2021-08-30 /pmc/articles/PMC8530109/ /pubmed/34472454 http://dx.doi.org/10.4103/1673-5374.314291 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Ritala, Joel F.
Lyne, Seán B.
Sajanti, Antti
Girard, Romuald
Koskimäki, Janne
Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
title Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
title_full Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
title_fullStr Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
title_full_unstemmed Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
title_short Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
title_sort towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530109/
https://www.ncbi.nlm.nih.gov/pubmed/34472454
http://dx.doi.org/10.4103/1673-5374.314291
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