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Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)

BACKGROUND: The effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified. OBJECTIVE: Evaluate...

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Autores principales: Felício, João Soares, de Rider Britto, Hana Andrade, Cortez, Pedro Celeira, de Souza Resende, Fabrício, de Lemos, Manuela Nascimento, de Moraes, Lorena Vilhena, de Aquino, Vitória Teixeira, de Souza Parente, Fernanda, de Queiroz, Natércia Neves Marques, Abrahão Neto, João Felício, de Alcântara, Angélica Leite, da Silva, Wanderson Maia, de Souza Neto, Norberto Jorge Kzan, Freire Piani, Pedro Paulo, de Souza, Ícaro José Araújo, Silva, Lilian de Souza D’Albuquerque, de Oliveira, Maria Clara Neres Iunes, Said, Nivin Mazen, Nascimento de Lemos, Gabriela, de Melo, Franciane Trindade Cunha, Gomes, Daniela Lopes, Contente Braga de Souza, Ana Carolina, de Sá Oliveira dos Reis, Melissa, Leal, Valéria Suênya Galvão, Lobato, Isabel Jane Campos, Felício, Karem Miléo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530245/
https://www.ncbi.nlm.nih.gov/pubmed/34690928
http://dx.doi.org/10.3389/fendo.2021.723502
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author Felício, João Soares
de Rider Britto, Hana Andrade
Cortez, Pedro Celeira
de Souza Resende, Fabrício
de Lemos, Manuela Nascimento
de Moraes, Lorena Vilhena
de Aquino, Vitória Teixeira
de Souza Parente, Fernanda
de Queiroz, Natércia Neves Marques
Abrahão Neto, João Felício
de Alcântara, Angélica Leite
da Silva, Wanderson Maia
de Souza Neto, Norberto Jorge Kzan
Freire Piani, Pedro Paulo
de Souza, Ícaro José Araújo
Silva, Lilian de Souza D’Albuquerque
de Oliveira, Maria Clara Neres Iunes
Said, Nivin Mazen
Nascimento de Lemos, Gabriela
de Melo, Franciane Trindade Cunha
Gomes, Daniela Lopes
Contente Braga de Souza, Ana Carolina
de Sá Oliveira dos Reis, Melissa
Leal, Valéria Suênya Galvão
Lobato, Isabel Jane Campos
Felício, Karem Miléo
author_facet Felício, João Soares
de Rider Britto, Hana Andrade
Cortez, Pedro Celeira
de Souza Resende, Fabrício
de Lemos, Manuela Nascimento
de Moraes, Lorena Vilhena
de Aquino, Vitória Teixeira
de Souza Parente, Fernanda
de Queiroz, Natércia Neves Marques
Abrahão Neto, João Felício
de Alcântara, Angélica Leite
da Silva, Wanderson Maia
de Souza Neto, Norberto Jorge Kzan
Freire Piani, Pedro Paulo
de Souza, Ícaro José Araújo
Silva, Lilian de Souza D’Albuquerque
de Oliveira, Maria Clara Neres Iunes
Said, Nivin Mazen
Nascimento de Lemos, Gabriela
de Melo, Franciane Trindade Cunha
Gomes, Daniela Lopes
Contente Braga de Souza, Ana Carolina
de Sá Oliveira dos Reis, Melissa
Leal, Valéria Suênya Galvão
Lobato, Isabel Jane Campos
Felício, Karem Miléo
author_sort Felício, João Soares
collection PubMed
description BACKGROUND: The effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified. OBJECTIVE: Evaluate the relationship between 25-hydroxy-vitamin D [25(OH)D], HbA1c, and albuminuria in Diabetes Mellitus (DM). PATIENTS AND METHODS: Cross-sectional study with 1576 individuals with DM who had 25(OH)D, HbA1c, and albuminuria levels measured. Patients with abnormal creatinine levels were excluded, in order to avoid interference on VD levels by impaired kidney function. RESULTS: Patients with HbA1c ≥7% had lower 25(OH)D when compared to patients with HbA1c <7% (29.7 ± 10.2 vs 28.1 ± 9.9 ng/ml, p = 0.003) and 25(OH)D levels seems to predict 1.5% of HbA1c behavior. The 25(OH)D concentrations in patients with normoalbuminuria were higher than the levels observed in those with micro or macroalbuminuria (29.8 ± 9.0 vs 26.8 ± 8.6 and 25.1 ± 7.6, respectively, p = 0.001), patients who had 25(OH)D <20 ng/ml and 25(OH)D <30 ng/ml were at a higher risk of presenting albuminuria [OR = 2.8 (95% CI = 1.6 – 4.9), p<0.001, and OR = 2.1 (95% CI = 1.3 - 4.6), p<0.001, respectively]. In our regression model, albuminuria was influenced by HbA1c (r² = 0.076, p<0.00001) and 25(OH)D (r² = 0.018, p = 0.002) independently. CONCLUSION: Our study found an association between vitamin D levels, HbA1c and DKD. Additionally, our data suggest that the association between urinary albumin excretion and vitamin D levels is independent of glycemic control in patients with diabetes. Even though our patients presented normal creatinine levels, it is necessary further prospective studies to confirm if this association precedes or not the loss of renal function.
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spelling pubmed-85302452021-10-22 Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON) Felício, João Soares de Rider Britto, Hana Andrade Cortez, Pedro Celeira de Souza Resende, Fabrício de Lemos, Manuela Nascimento de Moraes, Lorena Vilhena de Aquino, Vitória Teixeira de Souza Parente, Fernanda de Queiroz, Natércia Neves Marques Abrahão Neto, João Felício de Alcântara, Angélica Leite da Silva, Wanderson Maia de Souza Neto, Norberto Jorge Kzan Freire Piani, Pedro Paulo de Souza, Ícaro José Araújo Silva, Lilian de Souza D’Albuquerque de Oliveira, Maria Clara Neres Iunes Said, Nivin Mazen Nascimento de Lemos, Gabriela de Melo, Franciane Trindade Cunha Gomes, Daniela Lopes Contente Braga de Souza, Ana Carolina de Sá Oliveira dos Reis, Melissa Leal, Valéria Suênya Galvão Lobato, Isabel Jane Campos Felício, Karem Miléo Front Endocrinol (Lausanne) Endocrinology BACKGROUND: The effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified. OBJECTIVE: Evaluate the relationship between 25-hydroxy-vitamin D [25(OH)D], HbA1c, and albuminuria in Diabetes Mellitus (DM). PATIENTS AND METHODS: Cross-sectional study with 1576 individuals with DM who had 25(OH)D, HbA1c, and albuminuria levels measured. Patients with abnormal creatinine levels were excluded, in order to avoid interference on VD levels by impaired kidney function. RESULTS: Patients with HbA1c ≥7% had lower 25(OH)D when compared to patients with HbA1c <7% (29.7 ± 10.2 vs 28.1 ± 9.9 ng/ml, p = 0.003) and 25(OH)D levels seems to predict 1.5% of HbA1c behavior. The 25(OH)D concentrations in patients with normoalbuminuria were higher than the levels observed in those with micro or macroalbuminuria (29.8 ± 9.0 vs 26.8 ± 8.6 and 25.1 ± 7.6, respectively, p = 0.001), patients who had 25(OH)D <20 ng/ml and 25(OH)D <30 ng/ml were at a higher risk of presenting albuminuria [OR = 2.8 (95% CI = 1.6 – 4.9), p<0.001, and OR = 2.1 (95% CI = 1.3 - 4.6), p<0.001, respectively]. In our regression model, albuminuria was influenced by HbA1c (r² = 0.076, p<0.00001) and 25(OH)D (r² = 0.018, p = 0.002) independently. CONCLUSION: Our study found an association between vitamin D levels, HbA1c and DKD. Additionally, our data suggest that the association between urinary albumin excretion and vitamin D levels is independent of glycemic control in patients with diabetes. Even though our patients presented normal creatinine levels, it is necessary further prospective studies to confirm if this association precedes or not the loss of renal function. Frontiers Media S.A. 2021-10-07 /pmc/articles/PMC8530245/ /pubmed/34690928 http://dx.doi.org/10.3389/fendo.2021.723502 Text en Copyright © 2021 Felício, de Rider Britto, Cortez, de Souza Resende, de Lemos, de Moraes, de Aquino, de Souza Parente, de Queiroz, Abrahão Neto, de Alcântara, da Silva, de Souza Neto, Freire Piani, de Souza, Silva, de Oliveira, Said, Nascimento de Lemos, de Melo, Gomes, Contente Braga de Souza, de Sá Oliveira dos Reis, Leal, Lobato and Felício https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Felício, João Soares
de Rider Britto, Hana Andrade
Cortez, Pedro Celeira
de Souza Resende, Fabrício
de Lemos, Manuela Nascimento
de Moraes, Lorena Vilhena
de Aquino, Vitória Teixeira
de Souza Parente, Fernanda
de Queiroz, Natércia Neves Marques
Abrahão Neto, João Felício
de Alcântara, Angélica Leite
da Silva, Wanderson Maia
de Souza Neto, Norberto Jorge Kzan
Freire Piani, Pedro Paulo
de Souza, Ícaro José Araújo
Silva, Lilian de Souza D’Albuquerque
de Oliveira, Maria Clara Neres Iunes
Said, Nivin Mazen
Nascimento de Lemos, Gabriela
de Melo, Franciane Trindade Cunha
Gomes, Daniela Lopes
Contente Braga de Souza, Ana Carolina
de Sá Oliveira dos Reis, Melissa
Leal, Valéria Suênya Galvão
Lobato, Isabel Jane Campos
Felício, Karem Miléo
Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)
title Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)
title_full Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)
title_fullStr Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)
title_full_unstemmed Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)
title_short Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)
title_sort association between 25(oh)vitamin d, hba1c and albuminuria in diabetes mellitus: data from a population-based study (vidamazon)
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530245/
https://www.ncbi.nlm.nih.gov/pubmed/34690928
http://dx.doi.org/10.3389/fendo.2021.723502
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